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首页> 外文期刊>World Journal of Gastroenterology >Effect of Helicobacter pylori infection on Bax protein expression in patients with gastric precancerous lesions.
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Effect of Helicobacter pylori infection on Bax protein expression in patients with gastric precancerous lesions.

机译：幽门螺杆菌感染对胃癌前病变患者Bax蛋白表达的影响。

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AIM: To investigate the effect of Helicobacter pylori (H pylori) infection on Bax protein expression, and explore the role of H pylori in gastric carcinogenesis. METHODS: H pylori was assessed by rapid urease test and Warthin-Starry method, and expression of Bax protein was examined immunohistochemically in 72 patients with pre-malignant lesions. RESULTS: Bax protein was differently expressed in intestinal metaplasia and gastric dysplasia, and showed 63.99% positivity. The positivity of Bax protein expression in H pylori-positive gastric precancerous lesions (72.3%) was significantly higher than that in H pylori-negative gastric precancerous lesions (48.0%, chi(2) = 4.191, P<0.05). H pylori infection was well correlated with the expression of Bax protein in gastric precancerous lesions (r = 0.978, P<0.01). After eradication of H pylori, the positivity of Bax protein expression significantly decreased in H pylori-positive gastric precancerous lesions (chi(2) = 5.506, P<0.05). In the persisting H pylori-infected patients, the positivity of Bax protein expression was not changed. CONCLUSION: H pylori infection may be involved in the upregulation of Bax gene, which might be one of the mechanisms of H pylori infection-induced gastric epithelial cell apoptosis. H pylori might act as a tumor promoter in the genesis of gastric carcinoma and eradication of H pylori could inhibit gastric carcinogenesis.
机译：目的：探讨幽门螺杆菌感染对Bax蛋白表达的影响，探讨幽门螺杆菌在胃癌发生中的作用。方法：采用快速尿素酶试验和Warthin-Starry法对幽门螺杆菌进行评估，并对72例恶性前病变患者进行免疫组化检测Bax蛋白的表达。结果：Bax蛋白在肠上皮化生和胃异型增生中表达差异，阳性率为63.99％。幽门螺杆菌阳性胃癌前病变中Bax蛋白表达的阳性率（72.3％）明显高于幽门螺杆菌阴性胃癌前病变中的Bax蛋白表达阳性率（48.0％，chi（2）= 4.191，P <0.05）。幽门螺杆菌感染与胃癌前病变中Bax蛋白的表达高度相关（r = 0.978，P <0.01）。根除幽门螺杆菌后，幽门螺杆菌阳性胃癌前病变中Bax蛋白表达的阳性率明显降低（chi（2）= 5.506，P <0.05）。在持续感染幽门螺杆菌的患者中，Bax蛋白表达的阳性没有改变。结论：幽门螺杆菌感染可能与Bax基因的上调有关，可能是幽门螺杆菌感染引起胃上皮细胞凋亡的机制之一。幽门螺杆菌可能在胃癌的发生中起着肿瘤的促进作用，根除幽门螺杆菌可以抑制胃癌的发生。

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