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首页> 外文期刊>World Journal of Gastroenterology >Low circulating levels of gastrin-17 in patients with Barrett's esophagus.
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Low circulating levels of gastrin-17 in patients with Barrett's esophagus.

机译：Barrett食管患者胃泌素17的循环水平低。

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AIM: To examine whether the fasting levels of serum gastrin-17 (G-17) are lower in Barrett's esophagus (BE) patients than in non-Barrett controls. METHODS: Nineteen patients with BE (presenting with a tubular segment >=2 cm long in lower esophagus and intestinal metaplasia of incomplete type ("pecialized columnar epithelium") in endoscopic biopsies from the tubular segment below the squamocolumnar junction were collected prospectively from outpatients referred to diagnostic gastroscopy. The controls comprised 199 prospectively collected dyspeptic outpatients without BE or any endoscopically visible lesions in the upper GI tract. Fasting levels of serum G-17 (G-17fast) were assayed with an EIA test using a mAb highly specific to amidated G-17. None of the patients and controls received therapy with PPIs or other antisecretory agents. RESULTS: The mean and median levels of G-17fast in serum were significantly lower (P = 0.001) in BE patients than in controls. The positive likelihood ratios (LR+) of low G-17fast to predict BE in the whole study population at G-17fast levels <0.5, <1, or <1.5 pmol/L were 3.5, 3.0, and 2.8, respectively. Among patients and controls with healthy stomach mucosa, the LR+ were 5.6, 3.8, and 2.6, respectively. In the whole study population, serum G-17 was below 2 pmol/L in 15 of 19 BE patients (79%). The corresponding prevalence was 66 of 199 (33%) in controls (P<0.001). The G-17fast was 5 pmol/L or more in only one of the 19 BE patients (5%). In controls, 76 of the 199 patients (38%) had such high serum G-17fast levels (P<0.01). CONCLUSION: Serum levels of G-17fast tend to be lower in native patients with BE than in healthy controls.
机译：目的：研究巴雷特食管（BE）患者的血清胃泌素17（G-17）的禁食水平是否低于非巴雷特对照者。方法：前瞻性从门诊就诊的患者中收集了19例BE（在下食道中的管状段长≥2cm，内膜活检中不完全类型的肠化生（“特殊柱状上皮”））。对照组包括199名前瞻性收集的消化不良的门诊患者，无BE或上消化道内窥镜可见病灶，采用EIA试验使用高度酰胺化的mAb进行EIA检测，测定血清G-17的空腹水平（G-17fast） G-17：没有患者和对照组接受过PPI或其他抗分泌药物的治疗结果：BE患者血清中G-17fast的平均水平和中位数水平显着低于对照组（P = 0.001）。低G-17fast预测整个研究人群中G-17fast水平<0.5，<1或<1.5 pmol / L的比率（LR +）分别为3.5、3.0和2.8 ly。在患有健康胃粘膜的患者和对照组中，LR +分别为5.6、3.8和2.6。在整个研究人群中，19名BE患者中有15名血清G-17低于2 pmol / L（79％）。对照组中相应的患病率为199例中的66例（33％）（P <0.001）。 19名BE患者中只有1名（5％）G-17fast为5 pmol / L或更高。在对照组中，199例患者中有76例（38％）具有如此高的血清G-17fast水平（P <0.01）。结论：BE天然患者血清G-17fast水平低于健康对照组。

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