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首页> 外文期刊>World Journal of Gastroenterology >Prognostic implication of isolated tumor cells and micrometastases in regional lymph nodes of gastric cancer.
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Prognostic implication of isolated tumor cells and micrometastases in regional lymph nodes of gastric cancer.

机译：胃癌区域淋巴结中孤立的肿瘤细胞和微转移灶的预后意义。

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AIM: To determine the prognostic significance of isolated tumor cells (ITCs) and lymph node micrometastases in gastric cancer. METHODS: Hematoxylin and eosin-stained slides of lymph node dissections of 632 consecutive gastric cancers were reviewed. Cytokeratin immunostaining was performed in 280 node-negative cases and 5 cases indefinite for lymph node metastases. Lymph node metastases were divided into ITCs, micrometastases, or macrometastases, according to the sizes of tumor deposits in largest dimension. ITCs were further classified into four groups according to metastasis pattern. RESULTS: Lymph node metastases were identified by immunostaining in 58 of 280 node-negative cases (20.7%) and were not significantly associated with patient survival (P = 0.3460). After cytokeratin immunostaining, 196 cases were classified as pN1, which consisted of 20 cases with micrometastases detected by immunostaining (pN1mi(i+)), 34 cases with only micrometastases (pN1mi), and 142 cases with pN1 with one or more macrometastases (pN1). Cases with pN1mi and pN1mi(i+) had a significantly better prognosis than the cases with pN1 (P = 0.0037). ITCs were found in 38 of these 58 cases, and could be divided into four groups: 12 cases with only a single cell pattern, 7 cases with multiple individual cells, 5 cases with single small cluster, and 14 cases with multiple small clusters. Among these four groups, cases with ITCs of multiple individual cell pattern showed the worst survival (median survival: 28 mo, P<0.0001). CONCLUSION: Both size and pattern of lymph node metastases can give prognostic information on the survival of gastric cancer patients.
机译：目的：确定孤立的肿瘤细胞（ITC）和淋巴结微转移在胃癌中的预后意义。方法：回顾了苏木精和曙红染色的632例连续胃癌淋巴结清扫载玻片。 280例淋巴结阴性病例和5例不确定的淋巴结转移病例进行了细胞角蛋白免疫染色。根据肿瘤沉积物的最大尺寸，将淋巴结转移分为ITC，微转移或巨转移。根据转移模式，ITC进一步分为四类。结果：在280例淋巴结阴性病例中有58例（20.7％）通过免疫染色鉴定出淋巴结转移，与患者生存率无显着相关性（P = 0.3460）。细胞角蛋白免疫染色后，分类为pN1的196例，包括20例通过免疫染色检测的微转移（pN1mi（i +）），34例仅微转移（pN1mi）和142例pN1并具有一个或多个宏观转移（pN1）。 。 pN1mi和pN1mi（i +）病例的预后明显优于pN1病例（P = 0.0037）。在这58例病例中的38例中发现了ITC，可以将其分为四类：12例仅具有单个细胞模式，7例具有多个单个细胞，5例具有单个小簇和14例具有多个小簇。在这四个组中，具有多个单个细胞模式的ITC病例显示出最差的生存率（中位生存期：28 mo，P <0.0001）。结论：淋巴结转移的大小和方式均可为胃癌患者的生存提供预后信息。

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