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首页> 外文期刊>World Journal of Gastroenterology >Cell cycle and radiosensitivity of progeny of irradiated primary cultured human hepatocarcinoma cells.
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Cell cycle and radiosensitivity of progeny of irradiated primary cultured human hepatocarcinoma cells.

机译：辐射的原代培养人肝癌细胞的子代的细胞周期和放射敏感性。

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AIM:To evaluate the change of growth characteristics and radiosensitivity of irradiated primary cultured human hepatocarcinoma cells.METHODS:All tumor tissue samples were obtained from 39 hepatocarcinoma patients with a mean age of 49.6 years (range 22-76 years). We divided the samples into irradiated group and non-irradiated group and measured their plating efficiency (PE), population doubling time (PDT), radiosensitivity index SF2 and cell cycle.RESULTS:The PDT of primary culture of hepatocarcinoma cells was 91.0+/-6.6 h, PE was 12.0+/-1.4%, SF2 was 0.41+/-0.05%. The PDT of their irradiated progeny was 124.8+/-5.8 h, PE was 5.0+/-0.7%, SF2 was 0.65+/-0.09%. The primary cultured human hepatocarcinoma cells showed significant S reduction and G(2) arrest in a dose-dependent manner. The progeny of irradiated primary cultured hepatocarcinoma cells grew more slowly and its radiosensitivity increased.CONCLUSION:The progeny of irradiated primary cultured human hepatocarcinoma cells grows more slowly and its radiosensitivity increases.
机译：目的：评价经照射的原代培养的人肝癌细胞的生长特性和放射敏感性的变化。方法：所有肿瘤组织样本均来自39例肝癌患者，平均年龄为49.6岁（22-76岁）。我们将样品分为辐照组和非辐照组，并测量其铺板效率（PE），群体倍增时间（PDT），放射敏感性指数SF2和细胞周期。结果：肝癌细胞原代培养的PDT为91.0 +/-。 6.6h，PE为12.0 +/- 1.4％，SF 2为0.41 +/- 0.05％。其辐射后代的PDT为124.8 +/- 5.8h，PE为5.0 +/- 0.7％，SF2为0.65 +/- 0.09％。原代培养的人类肝癌细胞显示出显着的S减少和G（2）逮捕以剂量依赖的方式。照射后的原代培养的肝癌细胞后代生长较慢，且放射敏感性增加。结论：照射后的原代培养的人肝癌细胞后代生长较慢，且放射敏感性增加。

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