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Surgical salvage therapy of anal cancer

机译：肛门癌的外科抢救疗法

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AIM: To evaluate the results of salvage resection in the management of persistent or locally recurrent anal canal cancer. METHODS: Details of all patients with anal canal cancer treated from 1978 to 1994 at Cancer Hospital of Chinese Academy of Medical Sciences (CAMS) were reviewed retrospectively. Sixteen patients who presented with persistent or locally recurrent anal canal cancer received salvage surgery. Before surgery all of the patients had received radiotherapy alone as their primary treatments. RESULTS: Of the 16 patients, 14 received salvage abdominoperineal resection (APR) and two had transanal local excision. There were no deaths attributable to operation. Delayed healing of the perineal wound occurred in eight patients. Complications unrelated to the perineal wound were found in five patients. The median follow-up time was 120 (range 5-245) months after salvage surgery. Nine patients died of disease progression, with a median survival time of 16 (range 5-27) months. Six patients had a long-term survival. CONCLUSION: Salvage resection after radiotherapy can yield a long-time survival in selected patients with anal canal cancer. However it offers little hope to patients with T_4 and/or N_(2-3) tumors.
机译：目的：评估在长期或局部复发的肛管癌治疗中挽救性切除的结果。方法：回顾性分析1978年至1994年在中国医学科学院肿瘤医院收治的所有肛管癌患者的病情。患有持续性或局部复发性肛管癌的16例患者接受了挽救性手术。手术前，所有患者均单独接受放射治疗作为其主要治疗方法。结果：在这16例患者中，有14例接受了挽救性腹腔手术切除（APR），其中2例经肛门局部切除。没有因手术死亡。会阴伤口的愈合延迟发生在八名患者中。在五名患者中发现了与会阴伤口无关的并发症。挽救手术后的中位随访时间为120（5-245）个月。 9名患者死于疾病进展，中位生存时间为16（5-27）个月。六例患者具有长期生存。结论：放疗后的挽救性切除可以使部分肛管癌患者获得长期生存。但是，它对患有T_4和/或N_（2-3）肿瘤的患者几乎没有希望。

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