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首页> 外文期刊>World Journal of Gastroenterology >Assessment of resin perfusion in hepatic failure in vitro and in vivo
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Assessment of resin perfusion in hepatic failure in vitro and in vivo

机译：体内和体外肝衰竭中树脂灌注的评估

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AIM: To observe the adsorbent effect of resin on endotoxin, cytokine, bilirubin in plasma of patients with hepatic failure and to determine the resin perfusion as an artificial liver support system in the treatment of hepatic failure. METHODS: One thousand milliliters of discarded plasma was collected from each of 6 severe hepatitis patients treated with plasma exchange. The plasma was passed through a resin perfusion equipment for 1-2 h via extracorporeal circulation, and then absorbent indicators of transaminase, bilirubin, blood ammonia, endotoxin and cytokines were examined. In the meantime, study of in vivo resin plasma perfusion was performed on 7 severe hepatitis patients to compare the changes of endotoxin and cytokines in blood before and after perfusion. RESULTS: The levels of total bilirubin, endotoxin, interleukin 1β and TNF-αin plasma were significantly decreased after in vitro resin plasma perfusion. The levels of interleukin 1β, TNF-α and endotoxin in blood were also evidently declined after in vivo resin plasma perfusion. Nevertheless, no obvious changes in IL-6, creatinine (Cr) and urea nitrogen (UN), blood ammonia and electrolytes were found both in vitro and in vivo. CONCLUSION: Bilirubin, endotoxin and cytokines in plasma of patients with hepatic failure can be effectively adsorbed by resin in vitro. Most cytokines and endotoxin in plasma can also be effectively removed by resin in vivo. It demonstrates that resin perfusion may have good treatment efficacy on hepatic failure and can be expected to slow down the progression of hepatic failure.
机译：目的：观察树脂对肝衰竭患者血浆中内毒素，细胞因子，胆红素的吸附作用，并确定树脂灌注作为人工肝支持系统治疗肝衰竭的作用。方法：从6名接受血浆置换治疗的严重肝炎患者中每人收集了1000毫升废弃血浆。血浆通过体外循环通过树脂灌注设备1-2小时，然后检查转氨酶，胆红素，血氨，内毒素和细胞因子的吸收指标。同时，对7例重症肝炎患者进行了体内树脂血浆灌注研究，以比较灌注前后血液中内毒素和细胞因子的变化。结果：体外树脂血浆灌注后，血浆总胆红素，内毒素，白介素1β和TNF-α水平明显降低。体内树脂血浆灌注后，血液中白介素1β，TNF-α和内毒素的水平也明显下降。尽管如此，在体内和体外均未发现IL-6，肌酐（Cr）和尿素氮（UN），血氨和电解质的明显变化。结论：肝衰竭患者血浆中的胆红素，内毒素和细胞因子可以被树脂有效地吸收。血浆中的大多数细胞因子和内毒素也可以在体内通过树脂有效去除。这表明树脂灌注对肝衰竭可能具有良好的治疗效果，并且有望减慢肝衰竭的进展。

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