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首页> 外文期刊>World Journal of Gastroenterology >Effect of Hejie decoction on T cell immune state of chronic hepatitis B patients
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Effect of Hejie decoction on T cell immune state of chronic hepatitis B patients

机译：和解汤对慢性乙型肝炎患者T细胞免疫状态的影响

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AIM: To explore the effect of Hejie decoction (HJD) (mediation decoction) on T cellular immune state of chronic hepatitis B patients. METHODS: Sixty-five patients with chronic hepatitis B were randomly divided into 2 groups. Forty patients in the treatment group were treated by HJD, and 25 patients in the control group were treated by routine Western medicine. The TCRVβ_7 gene expression, T lymphocyte subsets (CD_3~+, CD_4~+, CD_8~+, CD_4~+/CD_8~+) levels were observed before and after treatment. RESULTS: The level of CD_4~+ cells was lower whereas the level of CD_8~+ cells was higher in patients than in the normal group. There was no significant difference between the levels of CD_3~+ cells in patients and normal persons. After 6 months of treatment, ALT, AST, TB levels of the 2 groups were obviously decreased, and the level of CD_4~+ cells was increased whereas the level of CD_8~+ cells was decreased in the treatment group. However, the level of CD_4~+ cells and CD_8~+ cells had no significant difference in the control group. TCRVβ_7 expressions were detected in 6 patients of the treatment group, whose HBV-DNA and HBeAg turned negative and ALT became normal. HBeAg in another 3 patients turned negative while HBV-DNA did not, and TCRVβ_7 expressions were not detectable. TCRVβ_7 expression could not be detected in the control group, HBV-DNA of the control group did not turn negative. HBeAg in 1 patient turned negative while HBV-DNA did not, and TCRVβ_7 expressions were not detectable. The total effective rate was not significantly different between the 2 groups and the markedly effective rate was significantly different (P<0.01) CONCLUSION: HJD is effective for treating chronic hepatitis B, and its effect seems to relate with the improvement of the TCRVβ_7 expression of chronic hepatitis B patients, thus activating T cells and eliminating HBV. T cellular immune function plays an important role in HBV infection and virus elimination.
机译：目的：探讨和解汤（HJD）对慢性乙型肝炎患者T细胞免疫状态的影响。方法：将65例慢性乙型肝炎患者随机分为两组。治疗组40例接受HJD治疗，对照组25例接受常规西药治疗。观察治疗前后TCRVβ_7基因表达，T淋巴细胞亚群（CD_3〜+，CD_4〜+，CD_8〜+，CD_4〜+ / CD_8〜+）水平。结果：与正常组相比，患者的CD_4〜+细胞水平较低，而CD_8〜+细胞水平较高。患者和正常人的CD_3〜+细胞水平无明显差异。治疗6个月后，治疗组两组ALT，AST，TB水平明显降低，CD_4〜+细胞水平升高，而CD_8〜+细胞水平降低。然而，对照组的CD_4〜+细胞和CD_8〜+细胞水平无显着差异。在治疗组的6例患者中检测到TCRVβ_7表达，其中HBV-DNA和HBeAg转阴，ALT恢复正常。另外3例患者的HBeAg阴性，而HBV-DNA阴性，无法检测到TCRVβ_7表达。对照组未检测到TCRVβ_7表达，对照组HBV-DNA未见阴性。 1例患者HBeAg转阴，而HBV-DNA未转阴，未检测到TCRVβ_7表达。两组间总有效率无显着性差异，有显着性差异（P <0.01）。结论：HJD对慢性乙型肝炎有效，其作用似乎与TCRVβ_7表达的改善有关。慢性乙型肝炎患者，从而激活T细胞并消除HBV。 T细胞免疫功能在HBV感染和病毒清除中起重要作用。

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