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首页> 外文期刊>World Journal of Gastroenterology >Evaluation of the viability and energy metabolism of canine pancreas graft subjected to significant warm ischemia damage during preservation by UW solution cold storage method
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Evaluation of the viability and energy metabolism of canine pancreas graft subjected to significant warm ischemia damage during preservation by UW solution cold storage method

机译：UW溶液冷藏法评估犬胰腺移植物在保存过程中遭受明显的热缺血损伤的生存力和能量代谢

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摘要

AIM: To evaluate the viability and energy metabolism of long warm ischemically damaged pancreas during preservation by the UW solution cold storage method. METHODS: The pancreas grafts subjected to 30-120 min warm ischemia were preserved by the UW solution cold storage method for 24 h. The tissue concentrations of adenine nucleotides (AN) and adenosine triphosphate (ATP) and total adenine nucleotides (TAN) were determined by using high performance liquid chromatography (HPLC) and the viability of the pancreas graft was tested in the canine model of segmental pancreas autotransplantation. RESULTS: The functional success rates of pancreas grafts of groups after 30 min, 60 min, 90 min, 120 min of warm ischemia were 100%, 100%, 67.7%, 0%, respectively. There was an excellent correlation between the posttransplant viability and tissue concentration of ATP and TAN at the end of preservation. CONCLUSION: The UW solution cold storage method was effective for functional recovery of the pancreas suffering 60-min warm ischemia. The tissue concentration of ATP and TAN at the end of 24 h preservation by the UW solution cold storage method would predict the posttransplant outcome of pancreas graft subjected to significant warm ischemia.
机译：目的：通过超低温溶液冷存储法评估长期温暖的化学损伤的胰腺在保存过程中的活力和能量代谢。方法：采用UW溶液冷藏法保存30-120 min热缺血的胰腺移植物24 h。使用高效液相色谱（HPLC）测定腺嘌呤核苷酸（AN），三磷酸腺苷（ATP）和总腺嘌呤核苷酸（TAN）的组织浓度，并在分段胰腺自体移植的犬模型中测试胰腺移植物的生存力。结果：热缺血30分钟，60分钟，90分钟，120分钟后，各组胰腺移植的功能成功率分别为100％，100％，67.7％，0％。保存结束时，移植后的生存力与ATP和TAN的组织浓度之间存在极好的相关性。结论：UW溶液冷藏法能有效恢复60分钟热缺血胰腺的功能。 UW溶液冷藏法保存24 h结束时，ATP和TAN的组织浓度将预测胰腺移植物发生明显的局部缺血后的预后。

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