• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>World Journal of Gastroenterology >Microvessel density of malignant and benign hepatic lesions and MRI evaluation
【24h】

Microvessel density of malignant and benign hepatic lesions and MRI evaluation

机译：肝恶性病变的微血管密度及MRI评价

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

AIM: To study the difference of microvessel density (MVD) between malignant and benign hepatic lesions and study the relationship between MVD and dynamic enhanced magnetic resonance imaging (MRI) for evaluation of microvessels within malignant and benign hepatic lesions. METHODS: A total of 265 specimens of hepatocellular carcinoma (HCC), 122 cirrhosis tissues and 22 hepatic benign lesions were enrolled for MVD by immunohistochemistry on tissue microarray, of which 49 underwent MRI examination before surgery, then contrast-to-noise ratios (CNR) and enhancement index (EI) in all the phases were calculated. Pearson correlation was performed for correlation analysis between CNR, EI and MVD. RESULTS: MVD of HCC was 22.7+-15.8 (mean+-SD), which was obviously higher than that of cirrhosis tissue (8.3+-7.6, P<0.01), but was not statistically different from that of benign lesions (31.3+-22.7, P>0.05). Among HCC, MVD of gradesⅠ-Ⅱ was 29.9+-18.6, which was much higher than those of grade Ⅲ (22.2+-18.2, P<0.01) and gradeⅣ (22.9+-19.0, P<0.01). MVD of HCC (P=0.018) and of benign lesions (P=0.014) were both correlative with CNR in arterial phase. CONCLUSION: Neoangiogenesis is an important feature for malignant tumor, and MVD may act as a biological marker in differentiating malignant from benign hepatic lesions. Dynamic enhanced MRI, especially image in arterial phase, may act as an MVD evaluation criterion for malignant and benign hepatic lesions.
机译：目的：研究恶性和良性肝病灶之间的微血管密度（MVD）的差异，研究MVD与动态增强磁共振成像（MRI）的关系，以评估恶性和良性肝病灶内的微血管。方法：采用免疫组织化学方法在组织芯片上对265例肝细胞癌（HCC）标本，122例肝硬化组织和22例肝良性病变进行了MVD检查，其中49例在术前接受了MRI检查，然后进行了对比噪声比（CNR）检查。 ）和所有阶段的增强指数（EI）。对CNR，EI和MVD之间的相关性进行Pearson相关性分析。结果：肝癌MVD为22.7 + -15.8（平均值±SD），明显高于肝硬化组织（8.3 + -7.6，P <0.01），但与良性病变的差异无统计学意义（31.3 +-）。 22.7，P＞ 0.05）。在肝癌中，Ⅰ-Ⅱ级的MVD为29.9 + -18.6，远高于Ⅲ级（22.2 + -18.2，P <0.01）和Ⅳ级（22.9 + -19.0，P <0.01）。肝癌的MVD（P = 0.018）和良性病变的MVD（P = 0.014）均与动脉期CNR相关。结论：新血管生成是恶性肿瘤的重要特征，MVD可能是区分恶性和良性肝病变的生物学指标。动态增强MRI，尤其是动脉期的图像，可以作为MVD评估恶性和良性肝病变的标准。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号