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首页> 外文期刊>World Journal of Gastroenterology >Expression of mucins and E-cadherin in gastric carcinoma and their clinical significance
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Expression of mucins and E-cadherin in gastric carcinoma and their clinical significance

机译：黏蛋白和E-钙粘蛋白在胃癌中的表达及其临床意义

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摘要

AIM: To investigate the expression of three types of mucin (MUC1, MUC2, MUC5AC) and E-cadherin in human gastric carcinomas and their clinical significance. METHODS: Ninety-four gastric cancer specimens were classified according to WHO criteria and detected by immun-ohistochemical assay of expression of mucins and E-cadherin. RESULTS: The positive expression rates of MUC1, MUC2, MUC5AC and E-cadherin were 82% (77/94), 84% (79/94), 40% (38/94) and 56% (53/94) respectively. MUC1 expression was significantly correlated with the types of cancer (the positive rates of MUC1 in well and moderately differentiated tubular adenocarcinoma, poorly differentiated adenocarcinoma signet-ring cell carcinoma and mucinous carcinoma were 91%, 87%, 71%, 71%, respectively, P < 0.05), age of patients (the positive rates of it among the people who are younger than 40 years, between 40-60 years and over 60 year were 74%, 81%, 89%, P < 0.05), lymph nodes involvement (the positive rates in the non-interfered group and the interfered group were 78%, 85%, P < 0.05) and tumor size (the positive rates in the tumors with the size less than 3 cm, 3-6 cm and larger than 6 cm were 69%, 92%, 69%, P< 0.05); MUC2 expression was significantly associated with types of cancers and had the strongest expression in mucinous carcinomas (the positive rates of MUC2 in well and moderately differentiated tubular adenocarcinoma, poorly differentiated adenocarcinoma, signet-ring cell carcinoma and mucinous carcinoma were 94%, 70%, 81%, 100%, P < 0.05), but it had no obvious relation to age, gender, tumor location, lymph nodes involvement, depth of invasion and metastasis to extra-gastric organs (P > 0.05); MUC5AC expression was not related to any of the characteristics investigated except that it had relation to gender, whereas MUC5AC showed the tendency to higher expression in ess invasive lesions and lower expression in advanced stage cancers (P > 0.05); No significant difference was found for E-cadherin expression. There were strong positive relationships between the expression of MUC1 and E-cadherin, MUC2 and E-cadherin, MUC1 and MUC2 (R = 0.33, R = 0.22, R = 0.32, respectively, P < 0.05). According to the COX proportional hazards model, older patients, involvement of lymph nodes, different types of gastric cancer and MUC2 expression were significantly associated with poorer outcome of gastric carcinoma patients (β = 0.08, β = 3.94, β = 1.33, β = 0.75, respectively, P < 0.05). CONCLUSION: MUC1 and MUC2 are good markers of different types of gastric cancer. MUC2 is especially a good marker of mucinous carcinoma. MUC1, MUC2 may interfere with the function of E-cadherin in gastric carcinomas, and have synergic effect on progression of gastric cancers.
机译：目的：探讨三种黏蛋白（MUC1，MUC2，MUC5AC）和E-钙粘蛋白在人胃癌中的表达及其临床意义。方法：根据WHO标准对94例胃癌标本进行分类，并通过免疫组织化学法检测黏蛋白和E-钙粘蛋白的表达。结果：MUC1，MUC2，MUC5AC和E-cadherin的阳性表达率分别为82％（77/94），84％（79/94），40％（38/94）和56％（53/94）。 MUC1表达与癌症类型显着相关（在高分化和中分化肾小管腺癌，低分化腺癌印戒细胞癌和粘液癌中MUC1的阳性率分别为91％，87％，71％，71％， P <0.05），患者年龄（40岁以下，40-60岁至60岁以上人群中其阳性率分别为74％，81％，89％，P <0.05）受累（非干扰组和干扰组的阳性率分别为78％，85％，P <0.05）和肿瘤大小（小于3 cm，3-6 cm及更大的肿瘤中的阳性率小于6 cm的分别为69％，92％，69％，P <0.05）; MUC2表达与癌症类型显着相关，并且在粘液癌中表达最强（MUC2在高分化和中分化肾小管腺癌，低分化腺癌，印戒细胞癌和粘液癌中的阳性率分别为94％，70％， 81％，100％，P <0.05），但与年龄，性别，肿瘤位置，淋巴结受累，浸润深度和转移至胃外器官无明显关系（P> 0.05）； MUC5AC的表达与性别无关，与所研究的任何特征均无关，而MUC5AC则显示在侵袭性病变中较高的表达趋势，在晚期癌症中较低的表达趋势（P> 0.05）。 E-钙粘着蛋白表达没有发现显着差异。 MUC1和E-钙粘蛋白，MUC2和E-钙粘蛋白，MUC1和MUC2的表达之间有很强的正相关性（分别为R = 0.33，R = 0.22，R = 0.32，P <0.05）。根据COX比例风险模型，老年患者，淋巴结受累，不同类型的胃癌和MUC2表达与胃癌患者预后较差显着相关（β= 0.08，β= 3.94，β= 1.33，β= 0.75分别为P <0.05）。结论：MUC1和MUC2是不同类型胃癌的良好标志物。 MUC2特别是粘液癌的良好标记。 MUC1，MUC2可能会干扰E-钙黏着蛋白在胃癌中的功能，并对胃癌的进展具有协同作用。

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