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首页> 外文期刊>World Journal of Gastroenterology >Primary small cell carcinoma of esophagus: Report of 9 cases and review of literature
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Primary small cell carcinoma of esophagus: Report of 9 cases and review of literature

机译：原发性食管小细胞癌9例报告并文献复习

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AIM: To analyze the clinical manifestations, pathological features and treatment of primary small cell carcinoma (SCC) of the esophagus and to review the literature on this entity. METHODS: The records of 9 patients with primary esophageal small cell carcinoma were examined and the demographic data, presenting symptoms, methods of tumor diagnosis, and types of treatment given, response to treatment, pathologic findings, and clinical outcome were reviewed. Features of mixed patterns of histological differentiation and lymph node metastases were specifically sought. RESULTS: All the patients reported dysphagia, weight loss and chest pain as the initial symptoms. In 5 cases the tumors were located in the mid-esophagus, 3 cases in the lower third of the esophagus and 1 case in the upper third. The average length of esophageal involvement was 5 cm. They underwent radical resection, regional lymph node clearance and esophageal-stomach anastomosis in thorax or at neck. Two patients had a stage IIa disease, five had a stage IIb disease, and the other two had a stage III disease of International Union Contrele Cancer (UICC). All of them were historically and immunohistochemically confirmed SCC of esophagus. Immunohistochemical staining for neuron-specific enolase (NSE), synaptophsin (Syn) and chromogranin A exhibited strong immunoreactivity in all specimens. Three of the nine resected specimens showed foci of squamous cell carcinoma in situ. Metastasis was present in 7 of 9 adjacent lymph nodes. All the patients survived the operations and made an uneventful postoperative recovery. They received adjuvant systemic chemotherapy and local radiation therapy after discharge. During follow-up, three patients developed multiple liver, brain, lung and bone metastases and died between 5 and 18 mo after the diagnosis. Three patients developed widespread metastasis disease and died between 18 and 37 mo after the diagnosis. There was no local tumor recurrence in these 6 patients. The other three patients were lost during follow-up. CONCLUSION: Primary small cell carcinoma of the esophagus is a rare but very malignant tumor. Radical resection combined with chemotherapy and radiotherapy is helpful in limited stage cases.
机译：目的：分析食管原发性小细胞癌（SCC）的临床表现，病理特征和治疗方法，并复习有关该实体的文献。方法：检查9例原发性食管小细胞癌患者的病历，并回顾其人口统计学资料，表现症状，肿瘤诊断方法，所用治疗方法，对治疗的反应，病理结果和临床结局。特别寻求组织学分化和淋巴结转移混合模式的特征。结果：所有患者均以吞咽困难，体重减轻和胸痛为最初症状。 5例肿瘤位于食道中部，3例位于食管下三分之一，1例位于上三分之一。食道受累的平均长度为5厘米。他们进行了根治性切除，区域淋巴结清除和胸腔或颈部食管胃吻合术。两名患者患有IIa期疾病，五名患者患有IIb期疾病，另外两名患者则患有国际联合结肠癌（UICC）的III期疾病。所有这些均在历史上和免疫组织化学上证实了食管的SCC。神经元特异性烯醇化酶（NSE），突触蛋白（Syn）和嗜铬粒蛋白A的免疫组织化学染色在所有标本中均表现出较强的免疫反应性。切除的9个标本中有3个在原位显示了鳞状细胞癌灶。在9个相邻的淋巴结中有7个存在转移。所有患者均幸免于难，术后恢复良好。他们出院后接受了辅助全身化疗和局部放疗。在随访期间，三名患者发生了多处肝，脑，肺和骨转移，并在诊断后5至18 mo死亡。三名患者发展成广泛的转移性疾病，并在诊断后18至37 mo死亡。这6例患者中没有局部肿瘤复发。其余三名患者在随访过程中丢失。结论：原发性食管小细胞癌是一种罕见但非常恶性的肿瘤。根治性切除结合化学疗法和放射疗法在有限的病例中很有帮助。

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