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PTEN encoding product: a marker for tumorigenesis and progression of gastric carcinoma

机译：PTEN编码产物：胃癌发生和发展的标志物

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AIM: To detect the expression of PTEN encoding product in normal mucosa, intestinal metaplasia (IM), dysplasia and carcinoma of the stomach, and to investigate its clinical implication in tumorigenesis and progression of gastric carcinoma. METHODS: Formalin-fixed paraffin embedded specimens from 184 cases of gastric carcinoma, their adjacent normal mucosa, IM and dysplasia were evaluated for PTEN protein expression by SABC immunohistochemistry. PTEN expression was compared with tumor stage, lymph node metastasis, Lauren's and WHO's histological classification of gastric carcinoma. Expression of VEGF was also detected in 60 cases of gastric carcinoma and its correlation with PTEN was concerned. RESULTS: The positive rates of PTEN protein were 100% (102/102), 98.5%(65/66), 66.7% (4/6) and 47.8%(88/184) in normal mucosa, IM, dysplasia and carcinoma of the stomach, respectively. The positive rates in dysplasia and carcinoma were lower than in normal mucosa and IM (P<0.01). Advanced gastric cancers expressed less frequent PTEN than early gastric cancer (42.9% vs 67.6%, P<0.01). The positive rate of PTEN protein was lower in gastric cancer with than without lymph node metastasis (40.3% vs 63.3%, P<0.01). PTEN was less expressed in diffuse-type than in intestinal-type gastric cancer (41.5 % vs 57.8%, P<0.05). Signet ring cell carcinoma showed the expression of PTEN at the lowest level (25.0%, 7/28); less than well and moderately differentiated ones (P<0.01). Expression of PTEN was not correlated with expression of VEGF (P>0.05). CONCLUSION: Loss or reduced expression of PTEN protein occures commonly in tumorigenesis and progression of gastric carcinoma. It is suggested that PTEN can be an objective marker for pathologically biological behaviors of gastric carcinoma.
机译：目的：检测PTEN编码产物在正常胃黏膜，肠上皮化生，异型增生和胃癌中的表达，探讨其在胃癌发生发展中的临床意义。方法：采用SABC免疫组织化学方法检测184例胃癌及其邻近正常黏膜，IM和异型增生患者的福尔马林固定石蜡包埋标本。将PTEN表达与胃癌的肿瘤分期，淋巴结转移，Lauren's和WHO的组织学分类进行比较。在60例胃癌中也检测到VEGF的表达，并与PTEN相关。结果：正常黏膜，IM，异型增生和癌组织中PTEN蛋白的阳性率分别为100％（102/102），98.5％（65/66），66.7％（4/6）和47.8％（88/184）。胃。异型增生和癌的阳性率低于正常黏膜和IM（P <0.01）。晚期胃癌的PTEN发生率低于早期胃癌（42.9％比67.6％，P <0.01）。有淋巴结转移的胃癌中PTEN蛋白的阳性率较低（40.3％vs 63.3％，P <0.01）。 PTEN在弥散型胃癌中的表达少于肠道型胃癌（41.5％vs 57.8％，P <0.05）。印戒细胞癌的PTEN表达水平最低（25.0％，7/28）。低于中，中度分化者（P <0.01）。 PTEN的表达与VEGF的表达无关（P> 0.05）。结论：PTEN蛋白的表达缺失或减少通常发生在胃癌的发生和发展过程中。提示PTEN可以作为胃癌病理生物学行为的客观标志。

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