• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>World Journal of Gastroenterology >Relationship between expression of E-cadherin-catenin complex and clinicopathologic characteristics of pancreatic cancer
【24h】

Relationship between expression of E-cadherin-catenin complex and clinicopathologic characteristics of pancreatic cancer

机译：E-钙粘蛋白-连环蛋白复合物的表达与胰腺癌临床病理特征的关系

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

AIM: To investigate the expression of E-cadherin and alpha-catenin and beta-catenin in pancreatic carcinoma and its relationship with the clinicopathologic characteristics, and clarify the mechanism of invasion and metastasis of pancreatic cancer. METHODS: The expression of E-cadherin and alpha-, beta-catenin was examined in 47 cases of infiltrative ductal adenocarcinoma of pancreas and 12 adult normal pancreatic tissues by immunohistochemical technique. RESULTS: The immunoreactivity of E-cadherin and alpha-, beta-catenin was expressed by normal ductal and acinar cells with strong membranous staining at the intercellular border in 12 cases of adult normal pancreatic tissues. Abnormal expression of E-cadherin and alpha-, beta-catenin in 47 pancreatic carcinoma tissues was demonstrated in 53.2%, 61.7% and 68.1%, respectively. Both abnormal expression of E-cadherin and alpha-catenin significantly correlated with differentiation, lymph node and liver metastases (P<0.05, respectively), whereas aberrant beta-catenin expression only correlated with lymph node and liver metastases (P<0.001). Abnormal E-cadherin and alpha-, beta-catenin expression was not associated with tumor size, invasion and survival time of patients (P>0.05, all). CONCLUSION: Pancreatic cancer likely occurs in case of E-cadherin-catenin complex genes mutations or deletions and abnormal expression of proteins, which significantly correlate with the biologic character of the tumor and lymph node and liver metastases. It is suggested that the abnormal E-cadherin-catenin complex expression plays an important role in the development and progression of tumor, and thus may become a new marker in pancreatic cancer metastasis.
机译：目的：探讨E-cadherin，α-catenin和β-catenin在胰腺癌中的表达及其与临床病理特征的关系，阐明胰腺癌的侵袭转移机制。方法：采用免疫组织化学方法检测47例胰腺浸润性导管腺癌及12例成人正常胰腺组织中E-钙黏着蛋白和α-，β-连环蛋白的表达。结果：12例成人正常胰腺组织中，正常导管和腺泡细胞在细胞间边界处均具有强烈的膜性染色，表达E-cadherin和α-，β-catenin的免疫反应性。 E-钙粘着蛋白和α-，β-连环蛋白在47个胰腺癌组织中的异常表达分别显示为53.2％，61.7％和68.1％。 E-钙粘着蛋白和α-连环蛋白的异常表达均与分化，淋巴结转移和肝转移密切相关（分别为P <0.05），而β-连环蛋白的异常表达仅与淋巴结和肝转移相关（P <0.001）。 E-钙粘蛋白和α-，β-连环蛋白的异常表达与患者的肿瘤大小，侵袭和生存时间无关（P> 0.05，全部）。结论：胰腺癌可能发生于E-钙粘蛋白-连环蛋白复合基因突变或缺失以及蛋白表达异常，这与肿瘤，淋巴结和肝转移的生物学特性显着相关。提示E-cadherin-catenin复合物的异常表达在肿瘤的发生发展中起重要作用，可能成为胰腺癌转移的新标志。

著录项

  • 来源
    《World Journal of Gastroenterology》 |2003年第2期|p.368-372|共5页
  • 作者

    Yu-Jun Li; Xiang-Rui Ji;

  • 作者单位

    The Affiliated Hospital of Medical College, Qingdao University, 16 Jiangsu Rd, Qingdao 266003, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 消化系及腹部疾病;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号