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首页> 外文期刊>World Journal of Gastroenterology >Relative efficacy of some prokinetic drugs in morphine-induced gastrointestinal transit delay in mice
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Relative efficacy of some prokinetic drugs in morphine-induced gastrointestinal transit delay in mice

机译：某些促运动药物对吗啡诱导的小鼠胃肠运输延迟的相对功效

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AIM: To study the relative efficacy of cisapride, metoclopramide, domperidone, erythromycin and mosapride on gastric emptying (GE) and small intestinal transit (SIT) in morphine treated mice. METHODS: Phenol red marker meal was employed to estimate GE and SIT in Swiss albino mice of either sex. The groups included were control, morphine 1 mg/kg (s.c. 15 min before test meal) alone or with (45 min before test meal p.o.) cisapride 10 mg/kg, metoclopramide 20 mg/kg, domperidone 20 mg/kg, erythromycin 6 mg/kg and mosapride 20 mg/kg. RESULTS: Cisapride, metoclopramide and mosapride were effective in enhancing gastric emptying significantly (P<0.001) whereas other prokinetic agents failed to do so in normal mice. Metoclopramide completely reversed morphine induced delay in gastric emptying followed by mosapride. Metoclopramide alone was effective when given to normal mice in increasing the SIT. Cisapride, though it did not show any significant effect on SIT in normal mice, was able to reverse morphine induced delay in SIT significantly (P<0.001) followed by metoclopramide and mosapride. CONCLUSION: Metoclopramide and cisapride are most effective in reversing morphine-induced delay in gastric emptying and small intestinal transit in mice respectively.
机译：目的：研究西沙必利，甲氧氯普胺，多潘立酮，红霉素和莫沙必利对吗啡治疗小鼠胃排空（GE）和小肠转运（SIT）的相对功效。方法：采用酚红色标记粉评估两性的瑞士白化病小鼠的GE和SIT。对照组包括吗啡，吗啡1 mg / kg（试验餐前15分钟）或单独（或试验餐前45分钟）西沙必利10 mg / kg，胃复安20 mg / kg，多潘立酮20 mg / kg，红霉素6毫克/千克和莫沙必利20毫克/千克。结果：西沙必利，甲氧氯普胺和莫沙必利可有效增强胃排空（P <0.001），而其他促动力剂则不能。甲氧氯普胺完全逆转了吗啡引起的胃排空延迟，随后是莫沙必利。当给予正常小鼠单独甲氧氯普胺可有效提高SIT。西沙必利尽管对正常小鼠的SIT没有显示任何显着影响，但能够逆转吗啡诱导的SIT延迟（P <0.001），然后是甲氧氯普胺和莫沙必利。结论：甲氧氯普胺和西沙必利分别在逆转吗啡引起的小鼠胃排空延迟和小肠转运方面最有效。

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