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首页> 外文期刊>World Journal of Gastroenterology >The influence of Enteral Nutrition in postoperative patients with poor liver function
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The influence of Enteral Nutrition in postoperative patients with poor liver function

机译：肠内营养对术后肝功能不良患者的影响

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摘要

AIM: To investigate the safety, rationality and the practicality of enteral nutritional (EN) support in the postoperative patients with damaged liver function and the protective effect of EN on the gut barrier. METHODS: 135 patients with liver function of Child B or C grade were randomly allocated to enteral nutrition group (EN, 65 cases), total parenteral nutrition group (TRN, 40 cases) and control group (CON, 30 cases). Nutritional parameters, hepatic and kidney function indexes were measured at the day before operation, 5th and 10th day after the operation respectively. Comparison was made to evaluate the efficacy of different nutritional support. Urinary concentrations of lactulose(L) and mannitol(M) were measured by pulsed electrochemical detection(HPLC-PED) and the L/M ratio calculated to evaluate their effectiveness on protection of gut barrier. RESULTS: No significant damages in hepatic and kidney function were observed in both EN and TPN groups between pre- and postoperatively. EN group was the earliest one reaching the positive nitrogen balance after operation and with the lowest loss of body weight and there was no change in L/M ratio after the operation (0.026+-0.004) at the day 1 before operation, 0.030+-0.004 at the day 5 postoperative and 0.027+-0.005 at the day 10 postoperative), but the change in TPN group was significant at the day 5 postoperative (0.027+-0.003 vs 0.038+-0.009, P<0.01). CONCLUSION: EN is a rational and effective method in patients with hepatic dysfunction after operation and has significant protection effect on the gut barrier.
机译：目的：探讨肠内营养（EN）在肝功能受损患者术后的安全性，合理性和实用性，以及EN对肠屏障的保护作用。方法：将135例Child B或C级肝功能患者随机分为肠内营养组（EN，65例），全肠外营养组（TRN，40例）和对照组（CON，30例）。在手术前一天，手术后第5天和第10天分别测量营养参数，肝和肾功能指标。进行比较以评估不同营养支持的功效。通过脉冲电化学检测（HPLC-PED）测定尿中乳果糖（L）和甘露醇（M）的浓度，并计算L / M比，以评估其对肠屏障保护的有效性。结果：EN和TPN组在术前和术后均未观察到肝肾功能的明显损害。 EN组是手术后最早达到正氮平衡且体重损失最低的一组，并且在手术前第1天，L / M比（0.026 + -0.004）没有变化，0.030 +-术后第5天为0.004，术后10天为0.027 + -0.005），但术后5天TPN组的变化显着（0.027 + -0.003 vs 0.038 + -0.009，P <0.01）。结论：EN是治疗肝功能不全患者的一种合理有效的方法，对肠壁屏障有明显的保护作用。

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  • 来源
    《World Journal of Gastroenterology》 |2003年第4期|p.843-846|共4页
  • 作者

    Qing-Gang Hu; Qi-Chang Zheng;

  • 作者单位

    Department of Surgery, Xiehe hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 消化系及腹部疾病;
  • 关键词

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