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首页> 外文期刊>World Journal of Gastroenterology >Expression of estrogen receptor and estrogen receptor messenger RNA in gastric carcinoma tissues
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Expression of estrogen receptor and estrogen receptor messenger RNA in gastric carcinoma tissues

机译：胃癌组织中雌激素受体和雌激素受体信使RNA的表达

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AIM: To study estrogen receptor (ER) and estrogen receptor messenger RNA (ERmRNA) expression in gastric carcinoma tissues and to investigate their association with the pathologic types of gastric carcinoma. METHODS: The expression of ER and ERmRNA in gastric carcinoma tissues (15 males and 15 females, 42-70 years old) was detected by immunohistochemistry and in situ hybridization, respectively. RESULTS: The positive rate of ER (immunohistochemistry) was 33.3 % in males and 46.7 % in females. In Borrmann Ⅳ gastric carcinoma ER positive rate was greater than that in other pathologic types, and in poorly differentiated adenocarcinoma and signet ring cell carcinoma the positive rates were greater than those in other histological types of both males and females (P<0.05). The ER was more highly expressed in diffused gastric carcinoma than in non-diffused gastric carcinoma (P<0.05). The ER positive rate was also related to regional lymph nodes metastases (P<0.05), and was significantly higher in females above 55 years old, and higher in males under 55 years old (P<0.05). The ERmRNA (in situ hybridization) positive rate was 73.3 % in males and 86.7 % in females. The ERmRNA positive rates were almost the same in Borrmann Ⅰ, Ⅱ, Ⅲ and Ⅳ gastric carcinoma (P>0.05). ERmRNA was expressed in all tubular adenocarcinoma, poorly differentiated adenocarcinoma and signet ring cell carcinoma (P<0.05). The ERmRNA positive rate was related to both regional lymph nodes metastases and gastric carcinoma growth patterns, and was higher in both sexes above 55 years old but without statistical significance (P>0.05). The positive rate of ERmRNA expression by in situ hybridization was higher than that of ER expression by immunohistochemistry (P<0.05). CONCLUSION: ERmRNA expression is related to the pathological behaviors of gastric carcinoma, which might help to predict the prognosis and predict the effectiveness of endocrine therapy for gastric carcinoma.
机译：目的：研究胃癌组织中雌激素受体（ER）和雌激素受体信使RNA（ERmRNA）的表达，探讨其与胃癌病理类型的关系。方法：采用免疫组织化学和原位杂交技术检测胃癌组织中ER和ERmRNA的表达（男性15例，女性15例，年龄42-70岁）。结果：ER（免疫组织化学）阳性率在男性中为33.3％，在女性中为46.7％。在BorrmannⅣ型胃癌中，ER阳性率高于其他病理类型，在低分化腺癌和印戒细胞癌中，男性和女性的阳性率均高于其他组织学类型（P <0.05）。 ER在弥漫性胃癌中的表达高于非弥散性胃癌（P <0.05）。 ER阳性率也与区域淋巴结转移有关（P <0.05），在55岁以上的女性中明显较高，在55岁以下的男性中较高（P <0.05）。 ERmRNA（原位杂交）阳性率在男性中为73.3％，在女性中为86.7％。 BorrmannⅠ，Ⅱ，Ⅲ和Ⅳ型胃癌中ERmRNA阳性率几乎相同（P> 0.05）。 ERmRNA在所有肾小管腺癌，低分化腺癌和印戒细胞癌中均有表达（P <0.05）。 ERmRNA阳性率与区域淋巴结转移和胃癌的生长方式有关，在55岁以上的男性中较高，但无统计学意义（P> 0.05）。原位杂交检测ERmRNA表达阳性率高于免疫组织化学检测ER表达（P <0.05）。结论：ERmRNA的表达与胃癌的病理表现有关，可能有助于预测胃癌的预后和疗效。

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