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Changes of microvascular architecture, ultrastructure and permeability of rat jejunal villi at different ages

机译:不同年龄大鼠空肠绒毛微血管结构,超微结构和通透性的变化

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AIM: To investigate the changes of microvascular architecture, ultrastructure and permeability of rat jejunal villi at different ages. METHODS: Microvascular corrosion casting, scanning electron microscopy, transmission electron microscopy and Evans blue infiltration technique were used in this study. RESULTS: The intestinal villous plexus of adult rats consisted of arterioles, capillary network and venules. The marginal capillary extended to the base part of the villi and connected to the capillary networks of adjacent villi. In newborn rats, the villous plexus was rather simple, and capillary network was not formed. The villous plexus became cone-shaped and was closely arrayed in ablactation rats. In adult rats, the villous plexus became tongue-shaped and was enlarged both in height and width. In aged rats, the villous plexus shrank in volume and became shorter and narrower. The diametral ratio of villous arteriole to villous venule increased as animals became older. The number of endothelial holes, the thickness of basal membrane and the permeability of microvasculature were increased over the entire course of development from newborn period to aged period. CONCLUSION: The digestive and absorptive functions of the rat jejunum at different ages are highly dependent upon the state of villous microvascular architecture and permeability, and blood circulation is enhanced by collateral branches such as marginal capillary, through which blood is drained to the capillary networks of adjacent villi.
机译:目的:探讨不同年龄大鼠空肠绒毛微血管结构,超微结构和通透性的变化。方法:采用微血管腐蚀铸件,扫描电子显微镜,透射电子显微镜和伊文思蓝渗透技术。结果:成年大鼠肠道绒毛丛由小动脉,毛细血管网和小静脉组成。边缘毛细血管延伸到绒毛的基部,并连接到相邻绒毛的毛细血管网络。在新生大鼠中,绒毛丛非常简单,并且未形成毛细血管网络。绒毛状丛变成圆锥形,并在摘除大鼠中紧密排列。在成年大鼠中,绒毛丛变成舌状,并在高度和宽度上都增大。在老年大鼠中,绒毛丛的体积缩小,变短和变窄。随着动物年龄的增长,绒毛小动脉与绒毛小静脉的直径比增加。从新生到衰老的整个过程中,内皮孔的数量,基底膜的厚度和微血管的通透性均增加。结论:不同年龄大鼠空肠的消化和吸收功能高度依赖于绒毛微血管结构和通透性的状态,并通过侧支等分支分支促进血液循环,血液通过该分支分支排泄到空肠。邻近绒毛。

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