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首页> 外文期刊>World Journal of Gastroenterology >Type 2 diabetes mellitus affects eradication rate of Helicobacter pylori
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Type 2 diabetes mellitus affects eradication rate of Helicobacter pylori

机译：2型糖尿病影响幽门螺杆菌的根除率

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AIM: To study the eradication rate of Helicobacter pylori (Hp) in a group of type 2 diabetes and compared it with an age and sex matched non-diabetic group. METHODS: 40 diabetic patients (21 females, 19 males; 56+-7 years) and 40 non-diabetic dyspeptic patients (20 females, 20 males; 54+-9 years) were evaluated. Diabetic patients with dyspeptic complaints were referred for upper gastrointestinal endoscopies; 2 corpus and 2 antral gastric biopsy specimens were performed on each patient. Patients with positive Hp results on histopathological examination comprised the study group. Non-diabetic dyspeptic patients seen at the Gastroenterology Outpatient Clinic and with the same biopsy and treatment protocol formed the control group. A triple therapy with amoxycillin (1 g b.i.d), clarithromycin (500 mg b.i.d) and omeprazole (20 mg b.i.d.) was given to both groups for 10 days. Cure was defined as the absence of Hp infection assessed by corpus and antrum biopsies in control upper gastrointestinal endoscopies performed 6 weeks after completing the antimicrobial therapy. RESULTS: The eradication rate was 50 % in the diabetic group versus 85 % in the non-diabetic control group CONCLUSION: Type 2 diabetic patients showed a significantly lower eradication rate than controls which may be due to changes in microvasculature of the stomach and to frequent antibiotic usage because of recurrent bacterial infections with the development of resistant strains.
机译：目的：研究一组2型糖尿病患者中幽门螺杆菌（Hp）的根除率，并将其与年龄和性别相匹配的非糖尿病组进行比较。方法：对40例糖尿病患者（21例女性，19例男性； 56 + -7岁）和40例非糖尿病性消化不良患者（20例女性，20例男性，54 + -9岁）进行了评估。消化不良主诉的糖尿病患者因上消化道内镜检查而转诊；每例患者均进行了2例体检和2例胃窦胃活检标本。在组织病理学检查中Hp结果呈阳性的患者组成研究组。对照组是在胃肠病门诊就诊的非糖尿病消化不良患者，并具有相同的活检和治疗方案。两组均接受阿莫西林（1 g b.i.d），克拉霉素（500 mg b.i.d）和奥美拉唑（20 mg b.i.d.）的三联疗法治疗10天。治愈的定义是在完成抗菌治疗后第6周进行的对照上消化道内镜检查中，没有进行体和胃窦活检评估是否存在Hp感染。结果：糖尿病组的根除率为50％，非糖尿病对照组为85％。结论：2型糖尿病患者的根除率明显低于对照组，这可能是由于胃微脉管系统的改变和频繁抗生素的使用是由于耐药菌的发展引起的反复细菌感染。

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