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首页> 外文期刊>World Journal of Gastroenterology >Association of extra intestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype: Results of a 25-year follow-up study
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Association of extra intestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype: Results of a 25-year follow-up study

机译：匈牙利西部某省炎性肠病肠道外表现与疾病表型的关联：一项为期25年的随访研究的结果

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AIM: IBD is a systemic disease associated with a large number of extra intestinal manifestations (EIMs). Our aim was to determine the prevalence of EIMs in a large IBD cohort in Veszprem Province in a 25-year follow-up study. METHODS: Eight hundred and seventy-three IBD patients were enrolled (ulcerative colitis/UC/: 619, m/f: 317/302, mean age at presentation: 38.3 years, average disease duration: 11.2 years; Crohn's disease/CD/: 254, m/f: 125/129, mean age at presentation: 32.5 years, average disease duration: 9.2 years). Intestinal, extra intestinal signs and laboratory tests were monitored regularly. Any alteration suggesting an EIMs was investigated by a specialist. RESULTS: A total of 21.3 % of patients with IBD had EIM (UC: 15.0 %, CD: 36.6 %). Age at presentation did not affect the likelihood of EIM. Prevalence of EIMs was higher in women and in CD, ocular complications and primary sclerosing cholangitis (PSC) were more frequent in UC. In UC there was an increased tendency of EIM in patients with a more extensive disease. Joint complications were more frequent in CD (22.4 % vs UC 10.2 %, P<0.01). In UC positive family history increased the risk of joint complications (OR:3.63). In CD the frequency of type-1 peripheral arthritis was increased in patients with penetrating disease (P=0.028). PSC was present in 1.6 % in UC and 0.8 % in CD. Dermatological complications were present in 3.8 % in UC and 10.2 % in CD, the rate of ocular complications was around 3 % in both diseases. Rare complications were glomerulonephritis, autoimmune hemolytic anaemia and celiac disease. CONCLUSION: Prevalence of EIM in Hungarian IBD patients is in concordance with data from Western countries. The high number of EIM supports a role for complex follow-up in these patients.
机译：目的：IBD是一种与大量肠外表现（EIM）相关的系统性疾病。我们的目标是通过25年的随访研究来确定维斯普雷姆省一个大型IBD队列中EIM的患病率。方法：纳入873例IBD患者（溃疡性结肠炎/ UC /：619，男性/女性：317/302，就诊时平均年龄：38.3岁，平均病程：11.2岁；克罗恩病/ CD /： 254，男/女：125/129，就诊平均年龄：32.5岁，平均病程：9.2岁。定期监测肠，肠外征象和实验室检查。任何暗示EIM的更改均由专家进行了调查。结果：总共21.3％的IBD患者患有EIM（UC：15.0％，CD：36.6％）。出现时的年龄不影响EIM的可能性。女性和CD中EIM的发生率较高，UC中眼部并发症和原发性硬化性胆管炎（PSC）的发生率较高。在UC中，患有更广泛疾病的患者的EIM趋势增加。 CD患者的关节并发症发生率更高（22.4％vs UC 10.2％，P <0.01）。在UC中，阳性家族史增加了关节并发症的风险（OR：3.63）。在CD中，穿透性疾病患者的1型周围性关节炎发生率增加（P = 0.028）。 PSC在UC中占1.6％，在CD中占0.8％。皮肤并发症在UC中占3.8％，在CD中占10.2％，两种疾病中眼部并发症的发生率约为3％。罕见的并发症是肾小球肾炎，自身免疫性溶血性贫血和乳糜泻。结论：匈牙利IBD患者的EIM患病率与西方国家的数据一致。大量的EIM支持对这些患者进行复杂的随访。

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