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首页> 外文期刊>World Journal of Gastroenterology >Pan-enteric dysmotility, impaired quality of life and alexithymia in a large group of patients meeting ROME II criteria for irritable bowel syndrome
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Pan-enteric dysmotility, impaired quality of life and alexithymia in a large group of patients meeting ROME II criteria for irritable bowel syndrome

机译：符合ROME II肠易激综合征标准的一大批患者出现全肠运动障碍，生活质量下降和运动障碍

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AIM: Psychological factors, altered motility and sensation disorders of the intestine can be variably associated with irritable bowel syndrome (IBS). Such aspects have not been investigated simultaneously. The aim of this paper was to evaluate gastrointestinal motility and symptoms, psychological spectrum and quality of life in a large group of IBS patients in southern Italy. METHODS: One hundred IBS patients (F:M=73:27, age 48+-2 years, mean+-SE) fulfilling ROME II criteria matched with 100 healthy subjects (F:M=70:30,45+-2 years). Dyspepsia, bowel habit, alexithymia, psycho-affective profile and quality of life were assessed using specific questionnaires. Basally and postprandially, changes in gallbladder volumes and antral areas after liquid meal and orocaecal transit time (OCTT) were measured respectively by ultrasonography and H_2-breath test. Appetite, satiety, fullness, nausea, and epigastric pain/ discomfort were monitored using visual-analogue scales. RESULTS: Compared with controls, IBS patients had increased dyspepsia (score 12.6+-0.7 vs 5.1+0.2, P<0.0001), weekly bowel movements (12.3+-0.4 vs 5.5+-0.2, P<0. 00001, comparable stool shape), alexithymia (score 59. 1+-1.1 vs 40.5+-1.0, P=0.001), poor quality of life and psycho-affective profile. IBS patients had normal gallbladder emptying, but delayed gastric emptying (T_(50): 35.5+-1.0 vs 26.1+-0.6 min, P=0.00001) and OCTT (163.0+-5.4 vs 96.6+-1.8 min, P=0.00001). Fullness, nausea, and epigastric pain/ discomfort were greater in IBS than in controls. CONCLUSION: ROME II IBS patients have a pan-enteric dysmotility with frequent dyspepsia, associated with psychological morbidity and greatly impaired quality of life. The presence of alexithymia, a stable trait, is a novel finding of potential interest to detect subgroups of IBS patients with different patterns recoveed after therapy.
机译：目的：心理因素，肠蠕动改变和感觉障碍可能与肠易激综合症（IBS）有不同的相关性。这些方面尚未同时进行调查。本文的目的是评估意大利南部一大群IBS患者的胃肠动力和症状，心理谱和生活质量。方法：符合ROME II标准的100名IBS患者（F：M = 73：27，年龄48 + -2岁，平均+ -SE）与100名健康受试者（F：M = 70：30,45 + -2岁）相匹配。使用特定的问卷评估消化不良，排便习惯，运动障碍，心理情感档案和生活质量。分别通过超声检查和H_2呼吸试验测定了进食前后的胆囊体积和肛门区域的变化，并计算了口经时间（OCTT）。使用视觉模拟量表监测食欲，饱腹感，饱胀感，恶心和上腹部疼痛/不适。结果：与对照组相比，IBS患者消化不良增加（得分12.6 + -0.7 vs 5.1 + 0.2，P <0.0001），每周排便次数（12.3 + -0.4 vs 5.5 + -0.2，P <0。00001，可比的大便形状），运动障碍（得分59。1+ -1.1与40.5 + -1.0，P = 0.001），较差的生活质量和心理情感档案。 IBS患者的胆囊排空正常，但胃排空延迟（T_（50）：35.5 + -1.0 vs 26.1 + -0.6 min，P = 0.00001）和OCTT（163.0 + -5.4 vs 96.6 + -1.8 min，P = 0.00001） 。 IBS的饱腹感，恶心和上腹部疼痛/不适比对照组大。结论：ROME II IBS患者患有全肠运动障碍，经常有消化不良，并伴有心理疾病，严重损害了生活质量。检音障碍（一种稳定的特征）的存在是一种新颖的发现，其潜在的兴趣在于检测治疗后恢复的具有不同模式的IBS患者亚组。

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