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首页> 外文期刊>World Journal of Gastroenterology >Epithelial cell proliferation and glandular atrophy in lymphocytic gastritis: Effect of H pylori treatment
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Epithelial cell proliferation and glandular atrophy in lymphocytic gastritis: Effect of H pylori treatment

机译：淋巴细胞性胃炎的上皮细胞增殖和腺萎缩：幽门螺杆菌治疗的效果

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AIM: Lymphocytic gastritis is commonly associated with Helicobacter pylori infection. The presence of glandular atrophy and foveolar hyperplasia in lymphocytic gastritis suggests abnormalities in cell proliferation and differentiation, forming a potential link with the suspected association with gastric cancer. Our aim was to compare epithelial cell proliferation and morphology in H pylori associated lymphocytic gastritis and H pylori gastritis without features of lymphocytic gastritis, and to evaluate the effect of H pylori treatment. METHODS: We studied 14 lymphocytic gastritis patients with H py/ori infection. For controls, we selected 14 matched dyspeptic patients participating in another treatment trial whose H pylori infection had successfully been eradicated. Both groups were treated with a triple therapy and followed up with biopsies for 6-18 months (patients) or 3 months (controls). Blinded evaluation for histopathological features was carried out. To determine the cell proliferation index, the sections were labeled with Ki-67 antibody. RESULTS: Before treatment, lymphocytic gastritis was characterized by foveolar hyperplasia (P=0.001) and glandular atrophy in the body (P=0.008), and increased proliferation in both the body (P=0.001) and antrum (P=0.002). Proliferation correlated with foveolar hyperplasia and inflammation activity. After eradication therapy, the number of intraepithelial lymphocytes decreased in the body (P=0.004) and antrum (P=0.065), remaining higher than in controls (P<0.001). Simultaneously, the proliferation index decreased in the body from 0.38 to 0.15 (P=0.043), and in the antrum from 0.34 to 0.20 (P=0.069), the antral index still being higher in lymphocytic gastritis than in controls (P=0.010). Foveolar hyperplasia and glandular atrophy in the body improved (P=0.021), reaching the non-LG level. CONCLUSION: In lymphocytic gastritis, excessive epithelial cell proliferation is predominantly present in the body, where it associates with foveolar hyperplasia and glandular atrophy. These characteristic changes of lymphocytic gastritis are largely related to H pylori infection, as shown by their improvement after eradication. However, some residual deviation was still seen in lymphocytic gastritis, indicating either an abnormally slow improvement or the presence of some persistent abnormality.
机译：目的：淋巴细胞性胃炎通常与幽门螺杆菌感染有关。淋巴细胞性胃炎中腺体萎缩和小叶增生的存在提示细胞增殖和分化异常，与怀疑与胃癌的联系形成了潜在联系。我们的目的是比较幽门螺杆菌相关的淋巴细胞性胃炎和没有幽门螺杆菌性胃炎的幽门螺杆菌的上皮细胞增殖和形态，并评估幽门螺杆菌治疗的效果。方法：我们研究了14例H py / ori感染的淋巴细胞性胃炎患者。作为对照，我们选择了14位匹配的消化不良患者参加另一项治疗性幽门螺杆菌感染已成功根除的治疗试验。两组均接受三联疗法治疗，并进行活检6-18个月（患者）或3个月（对照）。对组织病理学特征进行盲评估。为了确定细胞增殖指数，将切片用Ki-67抗体标记。结果：治疗前，淋巴细胞性胃炎的特征是小叶增生（P = 0.001）和体内腺体萎缩（P = 0.008），以及体内（P = 0.001）和胃窦（P = 0.002）增生。增殖与小叶增生和炎症活动相关。根除治疗后，体内（P = 0.004）和胃窦（P = 0.065）的上皮内淋巴细胞数量减少，仍高于对照组（P <0.001）。同时，体内增殖指数从0.38下降到0.15（P = 0.043），胃窦的增殖指数从0.34下降到0.20（P = 0.069），淋巴细胞性胃炎的肛门指数仍然高于对照组（P = 0.010）。 。人体的中心凹增生和腺体萎缩得到改善（P = 0.021），达到非LG水平。结论：在淋巴细胞性胃炎中，体内主要存在过度的上皮细胞增殖，与上皮小叶增生和腺体萎缩有关。根除后的改善表明，淋巴细胞性胃炎的这些特征性变化很大程度上与幽门螺杆菌感染有关。但是，在淋巴细胞性胃炎中仍观察到一些残留偏差，表明异常缓慢的改善或某些持续性异常的存在。

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