...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>World Journal of Gastroenterology >Hepatocellular apoptosis after hepatectomy in obstructive jaundice in rats
【24h】

Hepatocellular apoptosis after hepatectomy in obstructive jaundice in rats

机译：大鼠梗阻性黄疸肝切除术后肝细胞凋亡

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

AIM: To investigate the hepatocellular apoptosis after hepatectomy in obstructive jaundice and biliary decompression rats. METHODS: After bile duct ligation for 7 days, rats were randomly divided into OB group in which the rats underwent 70 % hepatectomy, OB-CD group in which the rats underwent hepatectomy accompanied by choledochoduodenostomy, CD-Hx group in which the rats underwent choledochoduodenostomy and then received 70 % hepatectomy on the fifth day after biliary decompression. The control group (Hx group) only underwent hepatectomy. RESULTS: The level of total serum bilirubin and serum enzymes was significantly lower in CD-Hx group than in OB-CD and OB groups on day 1, 3 and 5 after hepatectomy. The apoptotic index was significantly lower in CD-Hx group than in OB-CD and OB groups on day 3 and 5. The oligonucleosomal DNA fragments and Caspase-3 activity were also lower in CD-Hx group than in OB-CD and OB groups 3 days after hepatectomy, without differences between CD-Hx and Hx groups. CONCLUSION: Hepatocellular apoptosis plays vital roles in jaundice rats, and biliary decompression is more effective in treatment of patients with severe jaundice before operation.
机译：目的：探讨梗阻性黄疸和胆道减压大鼠肝切除术后肝细胞凋亡。方法：胆管结扎7天后，将大鼠随机分为70％肝切除的OB组，进行肝胆管十二指肠吻合术的肝切除OB-CD组，进行胆总管十二指肠吻合术的CD-Hx组然后在胆道减压后的第五天接受70％的肝切除术。对照组（Hx组）仅接受肝切除术。结果：在肝切除术后第1、3和5天，CD-Hx组的总血清胆红素和血清酶水平明显低于OB-CD和OB组。在第3天和第5天，CD-Hx组的凋亡指数显着低于OB-CD和OB组。CD-Hx组的寡核小体DNA片段和Caspase-3活性也低于OB-CD和OB组肝切除术后3天，CD-Hx和Hx组之间无差异。结论：肝细胞凋亡在黄疸大鼠中起着至关重要的作用，胆道减压术对重度黄疸患者术前治疗更为有效。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号