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首页> 外文期刊>World Journal of Gastroenterology >Tumor suppressor gene p16 and Rb expression in gastric cardia precancerouslesions from subjects at a high incidence area in northern China
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Tumor suppressor gene p16 and Rb expression in gastric cardia precancerouslesions from subjects at a high incidence area in northern China

机译：北方高发地区胃card癌癌前病变中抑癌基因p16和Rb的表达

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CONCLUSION: The alterations of p16 and Rb protein may play a ro1e in the early stages of gastric cardia carcinogenesis. AIM: To further understand the molecular basis for gastric cardia carcinogenesis and to provide etiological clues. METHODS: Endoscopic mucosa biopsy and histopathological examinations were made on 37 subjects from a high incidence area for both esophageal and gastric cardia carcinomas in northern Chine. All the biopsy samples were fixed in 850 ml.~(-1) L alcohol and embedded in paraffin. Each block contained one piece of tissue and was serially section at 5 μm. Immunohistochemistry (ABC) was carried out on these gastric cadia samples to determine the alterations of p16 and Rb.
机译：结论：p16和Rb蛋白的改变可能在胃card门癌发生的早期发挥作用。目的：进一步了解胃card门癌变的分子基础，并提供病因学线索。方法：对中国北部高发地区食管和胃card门癌高发地区的37名受试者进行了内镜黏膜活检和组织病理学检查。将所有活检样品固定在850 ml。〜（-1）L酒精中，并包埋在石蜡中。每个块包含一块组织，并以5μm连续切片。在这些胃大肠样本上进行了免疫组织化学（ABC）以确定p16和Rb的变化。

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