Metallothionein expression in hepatocellular carcinoma

Geng-Wen Huang; Lian-Yue Yang

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Metallothionein expression in hepatocellular carcinoma

机译：金属硫蛋白在肝细胞癌中的表达

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CONCLUSION: Decrease of MTs expression in HCC may play a role in carcinogenesis of HCC. MTs are stained heterogenously in HCC. We can choose the anticancer agents according to the MTs concentration in HCC, which may improve the results of chemotherapy for HCC. AIM: To investigate the expression of metallothioneins (MTs), which were recently thought to have close relationship with tumors, in human hepatocellular carcinoma. METHODS: Histological specimens of 35 cases of primary human hepatocellular carcinoma with para-neoplastic liver tissue and 5 cases of normal liver were stained for MTs with monoclonal mouse anti-MTs serum (E9) by the immunohistochemical ABC technique.

机译：结论：肝癌中MTs表达的降低可能与肝癌的发生有关。 MT在HCC中异质染色。我们可以根据肝癌中MTs的浓度选择抗癌药，以改善肝癌的化疗效果。目的：研究金属硫蛋白（MTs）在人类肝细胞癌中的表达，金属硫蛋白（MTs）最近被认为与肿瘤密切相关。方法：采用免疫组织化学ABC技术对35例原发性副肿瘤肝组织肝细胞癌和5例正常肝的组织学标本进行MTs染色，采用单克隆小鼠抗MTs血清（E9）进行染色。

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来源
《World Journal of Gastroenterology》 |2002年第4期|p.650-653|共4页
作者
Geng-Wen Huang; Lian-Yue Yang;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
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1. Expression of metallothionein-1 and metallothionein-2 as a prognostic marker in hepatocellular carcinoma [J] . Park,Y., Yu,E. Journal of gastroenterology and hepatology . 2013,第9期

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2. Low metallothionein 1M expression association with poor hepatocellular carcinoma prognosis after curative resection [J] . J. Ding, S.C. Lu Genetics and Molecular Research . 2016,第4期

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6. ZNF479 downregulates metallothionein-1 expression by regulating ASH2L and DNMT1 in hepatocellular carcinoma [O] . Yi-Ju Wu, Bor-Sheng Ko, Shu-Man Liang, 2019

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7. Expression of metallothionein I/II and Ki-67 antigen in various histological types of basal cell carcinoma Expression of metallothionein I/II and Ki-67 antigen in various histological types of basal cell carcinoma [O] . Andrzej Bieniek, Bartosz Pula, Aleksandra Piotrowska, 2012

机译：金属硫蛋白I / II和Ki-67抗原在各种组织学类型的基底细胞癌中的表达金属硫蛋白I / II和Ki-67抗原在各种组织学类型的基底细胞癌中的表达

Metallothionein expression in hepatocellular carcinoma

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