Expression of focal adhesion kinase and α5 and β1 integrins in carcinomas and its clinical significance

Jian-Min Su; Lu Gui; Yi-Ping Zhou

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Expression of focal adhesion kinase and α5 and β1 integrins in carcinomas and its clinical significance

机译：黏着斑激酶，α5和β1整合素在癌中的表达及其临床意义

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CONCLUSION: FAK is a better marker for carcinogenesis and the progression of cancer than integrin α5 or β1 subunit, and it may be not only a transformation-linked enzyme but also a progression-linked enzyme. AIM: To detect the expression pattern of FAK (focal adhesion kinase) and integrin α5 and β1 subunits in different kinds of cancerous tissues and to study their correlation with clinicopathological data including tumor type, grade and lymph node status. METHODS: Using an immunohistochemical technique, we examined the expression of FAK and integrin and subunits in cancerous and noncancerous tissues obtained from 75 patients with gastric carcinomas, 21 colorectal carcinomas, 16 hepatocellular carcinomas, 20 uterocervical carcinomas, and 20 breast carcinomas.

机译：结论：FAK比整联蛋白α5或β1亚基是更好的癌变和癌症进展的标志物，它不仅是转化连接酶，而且可能是进展连接酶。目的：检测FAK（黏着斑激酶）以及整联蛋白α5和β1亚基在不同类型癌组织中的表达模式，并研究其与临床病理数据的相关性，包括肿瘤类型，分级和淋巴结状态。方法：我们采用免疫组织化学技术，检测了75例胃癌，21例大肠癌，16例肝细胞癌，20例宫颈癌和20例乳腺癌患者的癌性和非癌性组织中FAK和整联蛋白及其亚基的表达。

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《World Journal of Gastroenterology》 |2002年第4期|p.613-618|共6页
作者
Jian-Min Su; Lu Gui; Yi-Ping Zhou;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
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1. Astrocytoma adhesion to extracellular matrix: functional significance of integrin and focal adhesion kinase expression. [J] . Rutka JT, Muller M, Hubbard SL, Journal of Neuropathology and Experimental Neurology: Official Journal of the American Association of Neuropathologists, Inc . 1999,第2期

机译：星状细胞瘤对细胞外基质的粘附：整联蛋白和粘着斑激酶表达的功能意义。
2. Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats. [J] . Li F, Zhang Y, Wu C Journal of Cell Science . 1999,第Pta24期

机译：整联蛋白连接的激酶定位于细胞基质粘着斑，但不定位于细胞间粘附位点，整联蛋白连接的激酶的粘着斑定位受PINCH结合ANK重复的调控。
3. The regulation of integrin-mediated osteoblast focal adhesion and focal adhesion kinase expression by nanoscale topography [J] . Lim JY, Dreiss AD, Zhou ZY, Biomaterials . 2007,第10期

机译：纳米级地形学对整联蛋白介导的成骨细胞黏着斑和黏着斑激酶表达的调节
4. Expression and Clinical Significance of Claudin-7, Fas and Integrin ??1 in Gastric Carcinoma Tissues [C] . Li Hui, Wang Wenjie, Zhang Junhui, International Conference on Information Technology in Medicine and Education . 2015

机译：Claudin-7，Fas和整合素β1在胃癌组织中的表达及其临床意义
5. Using integrins to fine tune CD4+ T cell responses: How the integrin regulatory proteins calpain, PIPKIgamma'90, talin and focal adhesion kinase work together to regulate CD4+ T cell activation. [D] . Wernimont, Sarah A. 2011

机译：使用整合素来微调CD4 + T细胞反应：整合素调节蛋白calpain，PIPKIgamma'90，talin和黏着斑激酶如何协同作用来调节CD4 + T细胞活化。
6. Expression of focal adhesion kinase and α5 and β1 integrins in carcinomas and its clinical significance [O] . Jian-Min Su, Lu Gui, Yi-Ping Zhou, 2002

机译：黏着斑激酶α5和β1整合素在癌中的表达及其临床意义
7. Phosphorylation of Focal Adhesion Kinase at Tyr397 in Gastric Carcinomas and its Clinical Significance [O] . Lai, I-Rue, Chu, Pei-Yu, Lin, Hsiao-Sheng, 2010

机译：胃癌Tyr397处黏附激酶磷酸化及其临床意义。

Expression of focal adhesion kinase and α5 and β1 integrins in carcinomas and its clinical significance

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