Immunologic role of nitric oxide in acute rejection of golden hamster to rat liver xenotransplantation

Tong-Jin Diao; Tong-Ye Yuan; You-Lin Li

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Immunologic role of nitric oxide in acute rejection of golden hamster to rat liver xenotransplantation

机译：一氧化氮在大鼠仓鼠异种移植急性排斥反应中的免疫作用

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CONCLUSION: The degrees of acute rejection can be effectively repressed in golden hamster to rat liver xenografts with splenectomy and cyclosporine. Nitric oxide metabolites, and nitric oxide synthase and its isoenzymes, above all inducible NOS (iNOS) can be used as potential diagnostic markers for acute rejection in liver transplantation. The cellular localization of nitric oxide varies according to the immunologic status of liver xenografts, thus thinking that hepatocyte derived nitric oxide may be protective in the hyporesponsive state, but hepatic injury is likely triggered by centrilobular iNOS expression in the superresponsive state. AIM: To evaluate the immunologic role and expression significances of nitric oxide(NO), nitric oxide synthase (NOS),and its isoenzyme in acute rejection to liver xenografts from golden hamster in rat.

机译：结论：在金仓鼠中，脾切除术和环孢霉素可有效抑制急性仓鼠对大鼠肝异种移植的排斥反应。首先，一氧化氮代谢产物，一氧化氮合酶及其同工酶可以用作肝移植急性排斥反应的潜在诊断标志物。一氧化氮的细胞定位根据肝脏异种移植物的免疫状态而变化，因此认为肝细胞衍生的一氧化氮在低反应状态下可能是保护性的，但肝损伤可能由超反应状态下的小叶iNOS表达触发。目的：探讨一氧化氮（NO），一氧化氮合酶（NOS）及其同工酶在大鼠金黄地鼠对肝异种移植物急性排斥反应中的免疫学作用及其表达意义。

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《World Journal of Gastroenterology》 |2002年第4期|p.746-751|共6页
作者
Tong-Jin Diao; Tong-Ye Yuan; You-Lin Li;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
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1. Striatal TH-immunopositive fibers recover after an intrastriatal injection of 6-hydroxydopamine in golden hamsters treated with prednisolone: roles of tumor necrosis factor-α and inducible nitric oxide synthase in neurodegeneration. [J] . Sebastián Rodríguez, Kazuyuki Uchida, Hiroyuki Nakayama Neuroscience Research: The Official Journal of the Japan Neuroscience Society . 2013,第1a2期

机译：纹状体内注射6-羟基多巴胺在泼尼松龙处理后的金黄仓鼠中，纹状体TH免疫阳性纤维得以恢复：肿瘤坏死因子-α和诱导型一氧化氮合酶在神经变性中的作用。
2. Striatal TH-immunopositive fibers recover after an intrastriatal injection of 6-hydroxydopamine in golden hamsters treated with prednisolone: roles of tumor necrosis factor-α and inducible nitric oxide synthase in neurodegeneration. [J] . Sebastián Rodríguez, Kazuyuki Uchida, Hiroyuki Nakayama Neuroscience Research: The Official Journal of the Japan Neuroscience Society . 2013,第1a2期

机译：在用泼尼松龙治疗的金仓鼠中的6-羟基多胺中的脑内注射6-羟基多戊胺后恢复：肿瘤坏死因子-α和诱导型一氧化氮合酶在神经变性中的角质。
3. Cytokine production during the inhibition of acute vascular rejection in a concordant hamster-to-rat cardiac xenotransplantation model [J] . ZHANG Xiao-gang, L(U) Yi, WANG Bo, 中华医学杂志（英文版） . 2007,第002期

机译：在一致的仓鼠-大鼠心脏异种移植模型中，在抑制急性血管排斥反应过程中产生细胞因子
4. Effects of Mitochondrial-Targeted Antioxidants on Real-Time Blood Nitric Oxide and Hydrogen Peroxide Release in Acute Hyperglycemic Rats [C] . Matthew L. Bertolet, Michael Minni, Tyler Galbreath American Peptide Symposium . 2015

机译：线粒体靶向抗氧化剂对急性高血糖大鼠实时血液一氧化氮和过氧化氢释放的影响
5. The role of nitric oxide and prostaglandins in triggering and potentiation of the liver regeneration cascade. [D] . Schoen, Jodi M. 2002

机译：一氧化氮和前列腺素在肝再生级联的触发和增强中的作用。
6. Immunologic role of nitric oxide in acute rejection of golden hamster to rat liver xenotransplantation [O] . Tong-Jin Diao, Tong-Ye Yuan, You-Lin Li 2002

机译：一氧化氮在大鼠仓鼠异种移植急性排斥反应中的免疫作用
7. Immunologic role of nitric oxide in acute rejection of golden hamster to rat liver xenotransplantation [O] . Tong-Jin Diao 2002

机译：一氧化氮在黄金仓鼠急性排斥鼠肝异种术中的免疫作用

Immunologic role of nitric oxide in acute rejection of golden hamster to rat liver xenotransplantation

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