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首页> 外文期刊>World Journal of Gastroenterology >Mast cell density and the context of clinicopathological parameters and expression of p185, estrogen receptor, and proliferating cell nuclear antigen in gastric carcinoma
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Mast cell density and the context of clinicopathological parameters and expression of p185, estrogen receptor, and proliferating cell nuclear antigen in gastric carcinoma

机译：胃癌肥大细胞密度和临床病理参数以及p185，雌激素受体和增殖细胞核抗原的表达情况

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AIM: To investigate the relationship between the mast cell density (MCD) and the context of clinicopathological parameters and expression of p185, estrogen receptor (ER), and proliferating cell nuclear antigen (PCNA) in gastric carcinoma. METHODS: Mast cell, p185, ER, and PCNA were detected using immunohistochemical S-P labeling method. Mast cell was counted in tissue of gastric carcinoma and regional lymph nodes respectively, and involved lymph nodes (ILN) were examined as usual. RESULTS: MCD was significantly related to both age and depth of penetration (χ~2=4.688,P<0.05 for age and χ_2=9.350, P<0.01 for depth of penetration) between MCD>21/0,03 mm~2 and MCD≤21/0.03 mm~2 in 100 patients; MCD in 1-6 ILN group patients was significantly higher than that in 7-15 ILN or >15 ILN group patients (u=6.881, 8.055, P<0.01); There were significant differences intergroup in positive expression rate of p185, ER and PCNA between MCD >21/ 0.03 mm~2 and MCD≤21/0.03 mm~2 in 100 patients. CONCLUSION: Mast cell may have effect on inhibiting invasive growth of tumor, especially in the aged patients; The number of mast cells, in certain degree, may predicate the number of involved lymph nodes, which is valuable for assessment of prognosis; MCD was related to the expression of p185, ER, and PCNA in gastric carcinoma. It suggests that mast cell accumulation may inhibit the proliferation and the dissemination of the gastric carcinoma.
机译：目的：探讨胃癌中肥大细胞密度（MCD）与临床病理参数和p185，雌激素受体（ER）和增殖细胞核抗原（PCNA）表达之间的关系。方法：采用免疫组化S-P标记法检测肥大细胞，p185，ER和PCNA。分别在胃癌和局部淋巴结组织中计数肥大细胞，并照常检查累及的淋巴结（ILN）。结果：MCD> 21 / 0,03mm〜2与MCD之间的相关性与年龄和穿刺深度密切相关（χ〜2 = 4.688，年龄P <0.05，χ_2= 9.350，P <0.01穿刺深度）。 100例患者中MCD≤21/ 0.03 mm〜2; 1-6个ILN组患者的MCD明显高于7-15个ILN组或> 15个ILN组的患者（u = 6.881，8.055，P <0.01）；在100例患者中，MCD> 21 / 0.03 mm〜2和MCD≤21/ 0.03 mm〜2之间，p185，ER和PCNA的阳性表达率在组间存在显着差异。结论：肥大细胞可能具有抑制肿瘤侵袭性生长的作用，尤其是对老年患者。肥大细胞的数量在一定程度上可以预测受累淋巴结的数量，这对于评估预后具有重要价值。 MCD与胃癌中p185，ER和PCNA的表达有关。这表明肥大细胞的积累可能抑制胃癌的增殖和扩散。

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