Expression of the CagA gene of H. Pylori and application of its product

Han FC; Yan XJ; Su CZ

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Expression of the CagA gene of H. Pylori and application of its product

机译：幽门螺杆菌CagA基因的表达及其产物的应用

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Helicobacter pylori (Hp) plays an important role in the upper digestive tract diseases. It can be divided into two main groups (toxic and non-toxic Hp) according to the production of vacuolating cytotoxin (VacA). The toxic bacteria also produce tytotoxin associated protein A (CagA) which might have something to do with the transcription, folding, transportation or the function of VacA. Studies showed that CagA positive Hp (CagA Hp) accounted for more than 50/100 of all kinds of Hp, and peptic ulcer and gastric cancer were closely related to their infection~[1-7].

机译：幽门螺杆菌（Hp）在上消化道疾病中起重要作用。根据产生空泡的细胞毒素（VacA）的不同，可将其分为两个主要类别（有毒和无毒Hp）。有毒细菌还会产生与毒素相关的蛋白A（CagA），这可能与VacA的转录，折叠，转运或功能有关。研究表明，CagA阳性Hp（CagA Hp）占所有Hp的50/100以上，消化性溃疡和胃癌与其感染密切相关[1-7]。

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来源
《World Journal of Gastroenterology》 |2000年第1期|p.122-124|共3页
作者
Han FC; Yan XJ; Su CZ;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
关键词
Helicobacter infection; Helicobacter pylori; CagA;

机译：幽门螺杆菌感染;幽门螺杆菌;CagA;

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1. Low-positive antibody titer against Helicobacter pylori cytotoxin-associated gene A (CagA) may predict future gastric cancer better than simple seropositivity against H. pylori CagA or against H. pylori. [J] . Suzuki G, Cullings H, Fujiwara S, Cancer epidemiology, biomarkers and prevention: A publication of the American Association for Cancer Research . 2007,第6期

机译：针对幽门螺杆菌细胞毒素相关基因A（CagA）的低阳性抗体滴度可能比单纯针对幽门螺杆菌CagA或针对幽门螺杆菌的血清阳性反应更好地预测未来的胃癌。
2. IN-SILICO DESIGN OF ANTIGENIC PEPTIDES AND MOLECULAR CLONING OF CYTOTOXIN ASSOCIATED GENE (cagA) OF H. PYLORI IN AN EXPRESSION VECTOR [J] . K. A. M. Al-Challabi, A. S. J. Al-Muhanna, M. Sudhakar International Journal of Pharmaceutical Sciences and Research . 2019,第6期

机译：幽门螺杆菌表达载体的抗原肽的计算机模拟设计和细胞毒素相关基因（cagA）的分子克隆
3. Construction of prokaryotic expression system of 2 148-bp fragment from cagA gene and detection of cagA gene, CagA protein in Helicobacter pylori isolates and its antibody in sera of patients [J] . Jie Van, Yuan Wang, Shi-He Shao, World Journal of Gastroenterology . 2004,第8期

机译：cagA基因2 148 bp片段原核表达系统的构建及幽门螺杆菌分离株中cagA基因，CagA蛋白及其抗体的检测
4. Molecular Diagnosis of Helicobacter pylori Infection and Risk Factor of the Presence of cagA and vacA Genes [C] . Hassan A, Dwidar N, Helaly G Incorporating of the Australian Society for Biochemistry and Molecular Biology Combio . 2009

机译：幽门螺杆菌感染的分子诊断和CAGA和VACA基因存在的危险因素
5. Investigating pathogenic mechanisms of the Helicobacter pylori virulence factor CagA using transgenic expression in Drosophila melanogaster. [D] . Wandler, Anica Maria. 2012

机译：使用在果蝇中的转基因表达研究幽门螺杆菌毒力因子CagA的致病机制。
6. Expression of the CagA gene of H. pylori and application of its product [O] . Feng-Chan Han, Xiao-Jun Yan, Cheng-Zhi Su 2000

机译：幽门螺杆菌CagA基因的表达及其产物的应用
7. Low-Positive Antibody Titer against Helicobacter pylori Cytotoxin-Associated Gene A (CagA) May Predict Future Gastric Cancer Better Than Simple Seropositivity against H. pylori CagA or against H. pylori [O] . Gen Suzuki, Harry Cullings, Saeko Fujiwara, 2007

机译：对幽门螺杆菌细胞毒素相关基因A（CAGA）的低阳性抗体滴度可以预测未来的胃癌，而不是简单的血清阳性对H. Pylori Caga或抗幽门螺杆菌

Expression of the CagA gene of H. Pylori and application of its product

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