Antitumoral activity of low density lipoprotein- aclacinomycin complex in mice bearing H_22 tumor

Bi WX; Xu SD; Zhang PH

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Antitumoral activity of low density lipoprotein- aclacinomycin complex in mice bearing H_22 tumor

机译：低密度脂蛋白-阿克拉霉素复合物对荷H_22肿瘤小鼠的抗肿瘤活性

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Cancer cells, which proliferate rapidly need large amounts of cholesterol for new membrane synthesis, and high LDL receptor (LDLR) activity. LDL has been proposed as a useful discriminatory vehicle for the delivery of cytotoxic drugs to tumor cells~[1,2]. LDL presents many advantages as drug carriers That may circumvent many problems encountered With synthetic carriers~[3,4]: (1) LDL may deliver Highly lipophilic compounds with promising Cytotoxic effect.

机译：迅速增殖的癌细胞需要大量胆固醇来进行新的膜合成，并需要高LDL受体（LDLR）活性。已经提出了将LDL用作将细胞毒性药物递送至肿瘤细胞的有用的鉴别载体[1,2]。 LDL作为药物载体具有许多优势，可以避免合成载体[3,4]遇到的许多问题：（1）LDL可以提供具有良好细胞毒性作用的高度亲脂性化合物。

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来源
《World Journal of Gastroenterology》 |2000年第1期|p.140-142|共3页
作者
Bi WX; Xu SD; Zhang PH;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
关键词
hepatoma cells; lipoprotein; low density;

机译：肝癌细胞脂蛋白;低密度;

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1. Immunostimulatory activities of a low molecular weight antitumoral polysaccharide isolated from Agaricus blazei Murill (LMPAB) in Sarcoma 180 ascitic tumor-bearing mice. [J] . Niu YC, Liu JC, Zhao XM Die Pharmazie . 2009,第7期

机译：分离自姬松茸的低分子量抗肿瘤多糖（LMPAB）在肉瘤180腹水的荷瘤小鼠中的免疫刺激活性。
2. Antitumoral activity and toxicity of PEG-coated and PEG-folate-coated pH-sensitive liposomes containing 159Gd-DTPA-BMA in Ehrlich tumor bearing mice [J] . SoaresD.C.F., CardosoV.N., DeBarrosA.L.B., European journal of pharmaceutical sciences . 2012,第1a2期

机译：含159Gd-DTPA-BMA的PEG包被和PEG叶酸包被的pH敏感脂质体的抗肿瘤活性和毒性
3. Liposomes radiolabeled with (159)Gd: in vitro antitumoral activity, biodistribution study and scintigraphic image in Ehrlich tumor bearing mice. [J] . Soares DC, de Oliveira MC, de Barros AL, European journal of pharmaceutical sciences . 2011,第4期

机译：用（159）Gd放射性标记的脂质体：荷Ehrlich荷瘤小鼠的体外抗肿瘤活性，生物分布研究和闪烁显像图像。
4. Biodistribution Study of /sup 99m/Tc Labeled Low Density Lipoprotein in B16 Melanoma Bearing Mice. Visualization of a Differential Fixation in Tumoral Tissue [C] . Ponty, E., Favre, . 2001

机译：/ sup 99m / Tc标记的低密度脂蛋白在带有B16黑色素瘤的小鼠中的生物分布研究。肿瘤组织中差异固定的可视化
5. Understanding electrostatics in polymersomes, monolayers, and worm-like micelles with application to NIR imaging and tumor-bearing mice. [D] . Christian, David Allan. 2009

机译：了解聚合物小体，单层膜和蠕虫状微团中的静电，并将其应用于近红外成像和荷瘤小鼠。
6. Antitumoral activity of low density lipoprotein-aclacinomycin complex in mice bearing H22 tumor [O] . Wen-Xiang Bi, Song-De Xu, Pei-Hai Zhang, 2000

机译：低密度脂蛋白-阿霉素复合物对荷H22肿瘤小鼠的抗肿瘤活性
7. Antitumor Activities of Low Molecular Weight Fraction Derived from the Cultured Fruit Body of Sparassis crispa in Tumor-Bearing Mice [O] . Kyosuke Yamamoto, Yoshihiro Nishikawa, Takashi Kimura, 2007

机译：低分子量级分的抗肿瘤活性衍生自肿瘤携带的小鼠培养的果实体体

Antitumoral activity of low density lipoprotein- aclacinomycin complex in mice bearing H_22 tumor

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