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首页> 外文期刊>Bulletin of Mathematical Biology >CODING OF STIMULUS INTENSITY IN AN OLFACTORY RECEPTOR NEURON: ROLE OF NEURON SPATIAL EXTENT AND PASSIVE DENDRITIC BACKPROPAGATION OF ACTION POTENTIALS
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CODING OF STIMULUS INTENSITY IN AN OLFACTORY RECEPTOR NEURON: ROLE OF NEURON SPATIAL EXTENT AND PASSIVE DENDRITIC BACKPROPAGATION OF ACTION POTENTIALS

机译：嗅觉神经元刺激强度的编码：神经元空间范围和被动电位的树突反向传播的作用

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The olfactory receptor neuron provides a good opportunity to analyze a biophysical model of a single neuron because its dendritic structure is simple and even close to a cylinder in the case of the moth sex-pheromone receptor cell. We have considered this cylindrical case and studied two main problems. First, we were concerned with the effect of the neuron's length on the receptor potential for a constant stimulus-induced conductance change. An analytical solution for the receptor potential was determined by using input resistances. It was shown that the longer the neuron, the greater its ability to code over a wide range of values of the intensity of the stimulus. Second, we studied numerically the passive backpropagation of action potentials into the dendrite and its influence on the firing frequency. While propagating along the dendrite the action potential decreases in amplitude and its shape becomes rounded. The firing frequency in the model with backpropagation was found to be greater than that obtained analytically in the absence of backpropagation. However, for any given conductance change, when normalized with respect to their maxima, both firing frequencies were found to be very similar over a wide range of parameter values. Therefore, the actual firing rate (with backpropagation) may be approximated by the analytical solution without backpropagation if the actual firing rate for a large conductance change is known.
机译：嗅觉受体神经元为分析单个神经元的生物物理模型提供了一个很好的机会，因为在蛾类性信息素受体细胞的情况下，其树突结构简单，甚至接近圆柱体。我们已经考虑了这种圆柱形情况，并研究了两个主要问题。首先，我们关注神经元长度对持续刺激引起的电导变化的受体电位的影响。通过使用输入电阻确定受体电位的分析溶液。结果表明，神经元越长，在刺激强度值的宽范围内进行编码的能力就越大。其次，我们从数值上研究了动作电位向枝晶的被动反向传播及其对点火频率的影响。沿树枝状晶体传播时，动作电位的幅度减小，其形状变圆。发现带有反向传播的模型中的触发频率大于没有反向传播的情况下通过分析获得的触发频率。但是，对于任何给定的电导率变化，当针对其最大值进行归一化时，发现两个触发频率在很宽的参数值范围内非常相似。因此，如果已知大电导变化的实际发射率，则实际发射速率（带有反向传播）可以通过无反向传播的分析解决方案来近似。

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