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首页> 外文期刊>Bulletin of the National Research Centre >Investigation of the Effect of Unfractionated and Low Molecular Weight Heparins on Inflammation and Gastrointestinal Mucosal Injury in Rats
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Investigation of the Effect of Unfractionated and Low Molecular Weight Heparins on Inflammation and Gastrointestinal Mucosal Injury in Rats

机译：低分子肝素对大鼠炎症和胃肠道黏膜损伤的影响研究

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The aim of the present work was to investigate the effect of unfractionated heparin (UFH; 1000-4000 IU/kg) in addition to three already marketed low molecular weight heparin (LMWH) preparations [nadroparin (1500-3000 anti-Xa IU/kg), tinzaparin (1500-3000 anti-Xa IU/kg), enoxaparin (300-600 anti-Xa IU/kg] on acute inflammation and on gastrointestinal mucosal integrity in rats. Acute inflammation was induced by intraplantar injection of carrageenan into rat hindpaw. Gastrointestinal mucosal injury was evoked by subcutaneous injection of indomethacin (20 mg/kg). The results showed that: (1) Different heparin preparations given s.c., 30 min prior to carrageenan injection exerted variable effects on the carrageenan oedema response. Oedema was not significanly changed after conventional UFH, but decreased after tinzaparin and nadroparin, the lower doses being more effective in reducing inflammation. Oedema was unchanged after enoxaparin at 600 IU/kg, but the lower dose of 300 IU/kg reduced oedema formation by 21.6% 1 h post-carrageenan.; (2) No significant change was noted in the number and severity of gastric mucosal lesions in rats treated with UFH. A significant decrease in number and severity of gastric mucosal lesions was noted in rats treated with the lower doses of either tinzaparin or enoxaparin compared with either the indomethacin control group or with the UFH (2000 IU/kg)-treated group. It is concluded that heparin preparations exert complex effects on acute (carrageenan-induced) inflammation and might have beneficial effects on gastric mucosal lesions caused by Indomethacin.
机译：本研究的目的是研究普通肝素（UFH; 1000-4000 IU / kg）的作用，以及三种已经上市的低分子量肝素（LMWH）制剂[萘达帕林（1500-3000 anti-Xa IU / kg） ），丁扎肝素（1500-3000 anti-Xa IU / kg），依诺肝素（300-600 anti-Xa IU / kg）对大鼠急性炎症和胃肠道黏膜完整性的影响。皮下注射消炎痛（20 mg / kg）引起胃肠道粘膜损伤，结果表明：（1）角叉菜胶注射前30 min给予不同剂量肝素的肝素对角叉菜胶水肿反应有不同作用。常规UFH后有明显改变，但替扎肝素和萘达普林后降低，降低剂量更有效地减轻炎症；依诺肝素在600 IU / kg后水肿没有改变，但较低的300 IU / kg剂量在角叉菜胶后1小时将水肿形成减少21.6％。 （2）用UFH治疗的大鼠胃黏膜病变的数量和严重程度没有明显变化。与消炎痛对照组或UFH（2000 IU / kg）治疗组相比，用较低剂量的替扎肝素或依诺肝素治疗的大鼠胃粘膜损伤的数量和严重程度明显降低。结论是，肝素制剂对急性（角叉菜胶诱导的）炎症具有复杂的作用，并且可能对消炎痛引起的胃粘膜损伤具有有益的作用。

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