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首页> 外文期刊>Calcified Tissue International >Estrogen and 'Exercise' Have a Synergistic Effect in Preventing Bone Loss in the Lumbar Vertebra and Femoral Neck of the Ovariectomized Rat
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Estrogen and 'Exercise' Have a Synergistic Effect in Preventing Bone Loss in the Lumbar Vertebra and Femoral Neck of the Ovariectomized Rat

机译：雌激素和“运动”对预防去卵巢大鼠腰椎和股骨颈的骨丢失具有协同作用

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摘要

This study was designed to study the individual or combined effects of estrogen and bipedal stance "exercise" on the lumbar vertebral body (LVB) and femoral neck (FN). At 6 months of age, six rats were sacrificed as baseline controls and all the others were either bilateral sham-ovariectomized or ovariectomized (OVX). Groups of OVX rats were housed in normal height cage (NC, 28 cm) or raised height cages (RC, 33 cm) and received biweekly s.c. injections of 10 mg/kg 17b estradiol (E2) or vehicle for 4 and 8 weeks. Histomorphometric measurements were performed on the undecalcified mid-transverse sections of the 4th LVB and FN. Ovariectomy alone induced cancellous bone loss by 21% and 39% in the LVB and FN, respectively; intracortical porosity area of the FN increased by 108% while total bone area did not change significantly because of the periosteal expansion following OVX. E2 alone partially prevented cancellous bone loss in the LVB and FN and prevented increased intracortical porosity area in the FN by reducing eroded surface and activation frequency. RC alone partially prevented the decrease of cancellous bone in the LVB and FN by reducing the bone-eroded surface but increased wall width. E2 plus RC completely preserved cancellous bone by having an additive effect on reducing eroded surface and activation frequency. RC helped to partially prevent decreased periosteal bone formation after estrogen administration. In conclusion, apart from inducing cancellous bone loss in the LVB and FN, OVX also increased intracortical remodeling in the FN. Estrogen prevented the overall activation of remodeling space induced by OVX. Apart from having similar effects as estrogen on remodeling space, RC induced positive bone balance within each remodeling unit. Combination treatment increased total bone mass beyond that of sham-control level by having an additive effect on lowering bone remodeling and increasing wall in both the LVB and FN.
机译：本研究旨在研究雌激素和双足姿势“锻炼”对腰椎体（LVB）和股骨颈（FN）的个体或联合作用。在6个月大时，处死六只大鼠作为基线对照，所有其他大鼠均为双侧假卵巢切除或卵巢切除（OVX）。将每组OVX大鼠放在正常身高笼（NC，28 cm）或升高身高笼（RC，33 cm）中，每两周一次。注射10 mg / kg的17b雌二醇（E2）或赋形剂，持续4周和8周。对第4 LVB和FN的未脱钙的中横切面进行组织形态计量学测量。仅卵巢切除术在LVB和FN中分别导致松质骨丢失21％和39％； FN的皮质内孔隙面积增加了108％，而总骨面积没有明显变化，因为OVX后的骨膜扩张。单独使用E2可以部分减少LVB和FN中的松质骨丢失，并通过减少侵蚀的表面和激活频率来防止FN中的皮质内孔隙面积增加。单独的RC通过减少骨侵蚀的表面但增加了壁的宽度部分地防止了LVB和FN中松质骨的减少。 E2和RC通过减少腐蚀表面和激活频率的累加效应，完全保留了松质骨。 RC帮助部分预防雌激素给药后骨膜减少。总之，除了在LVB和FN中引起松质骨丢失外，OVX还增加了FN中的皮质内重塑。雌激素阻止了OVX诱导的重塑空间的整体活化。除了在重塑空间上具有与雌激素相似的作用外，RC还可以在每个重塑单元内诱导出积极的骨骼平衡。组合治疗通过对LVB和FN的骨重构降低和壁增加具有累加作用，从而使总骨量超过了假对照水平。

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  • 来源
    《Calcified Tissue International》 |2003年第1期|42-49|共8页
  • 作者

    C.Y. Li; W.S.S. Jee; J.L. Chen; A. Mo; R.B. Setterberg; M. Su; X.Y. Tian; Y.F. Ling; W. Yao;

  • 作者单位

    Radiobiology Division University of Utah Salt Lake City Utah 84108-1218 USA;

    Radiobiology Division University of Utah Salt Lake City Utah 84108-1218 USA;

    Radiobiology Division University of Utah Salt Lake City Utah 84108-1218 USA;

    Radiobiology Division University of Utah Salt Lake City Utah 84108-1218 USA;

    Radiobiology Division University of Utah Salt Lake City Utah 84108-1218 USA;

    Radiobiology Division University of Utah Salt Lake City Utah 84108-1218 USA;

    Radiobiology Division University of Utah Salt Lake City Utah 84108-1218 USA;

    Radiobiology Division University of Utah Salt Lake City Utah 84108-1218 USA;

    Radiobiology Division University of Utah Salt Lake City Utah 84108-1218 USA;

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