Furanodienone induces cell cycle arrest and apoptosis by suppressing EGFR/HER2 signaling in HER2-overexpressing human breast cancer cells

Ying-Wei Li; Guo-Yuan Zhu; Xiao-Ling Shen; Jian-Hong Chu; Zhi-Ling Yu; Wang-Fun Fong

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Furanodienone induces cell cycle arrest and apoptosis by suppressing EGFR/HER2 signaling in HER2-overexpressing human breast cancer cells

机译：呋喃二烯酮可通过抑制HER2过表达的人乳腺癌细胞中的EGFR / HER2信号传导来诱导细胞周期停滞和凋亡

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Purpose Overexpression of EGFR and HER2 is seen in breast cancers and results in poor prognosis and decreased patient survival. Clinically, EGFR and HER2 are effective therapeutic targets. The objective of this study is to investigate the in vitro effects of furanodienone, an active chemical component isolated from Rhizoma Curcumae, on the activation of EGFR/HER2 signaling, cell cycle, and apoptosis in HER2-overexpressing BT474 and SKBR3 cells.

机译：目的在乳腺癌中发现EGFR和HER2的过表达，导致预后不良和患者生存期缩短。在临床上，EGFR和HER2是有效的治疗靶标。这项研究的目的是研究呋喃并二酮（一种从姜黄中提取的活性化学成分）对EGFR / HER2信号转导，细胞周期和HER2过表达BT474和SKBR3细胞凋亡的体外作用。

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《Cancer Chemotherapy and Pharmacology》 |2011年第5期|p.1315-1323|共9页
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Ying-Wei Li; Guo-Yuan Zhu; Xiao-Ling Shen; Jian-Hong Chu; Zhi-Ling Yu; Wang-Fun Fong;
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1. Furanodienone induces cell cycle arrest and apoptosis by suppressing EGFR/HER2 signaling in HER2-overexpressing human breast cancer cells. [J] . Li YW, Zhu GY, Shen XL, Cancer chemotherapy and pharmacology. . 2011,第5期

机译：呋喃二烯酮可通过抑制HER2过表达的人乳腺癌细胞中的EGFR / HER2信号传导来诱导细胞周期停滞和凋亡。
2. A novel dual EGFR/HER2 inhibitor KU004 induces cell cycle arrest and apoptosis in HER2-overexpressing cancer cells [J] . Tian Chongchong, Ding Pingping, Yuan Ziqiao, Apoptosis: An international journal on programmed cell death . 2015,第12期

机译：新型双重EGFR / HER2抑制剂KU004诱导HER2过表达的癌细胞的细胞周期停滞和凋亡
3. Interfering Transbody-mediated Her2 Gene Silencing Induces Apoptosis by G_0/G_1 Cell Cycle Arrest in Her2-overexpressing SK-BR-3 Breast Cancer Cells [J] . Aeyung Kim, Dong-Ki Choi, Eun-Sil Sung, Biotechnology and bioprocess engineering . 2012,第2期

机译：干扰抗体介导的Her2基因沉默诱导过表达Her2的SK-BR-3乳腺癌细胞中的G_0 / G_1细胞周期阻滞诱导凋亡。
4. Ugonin K induces Cell Cycle Arrest and Apoptosis through Reactive oxygen species/Apoptosis Signal Pathway in Human Skin Cancer Cells [C] . Leong-Perng Chan, Tzung-Han Chou, Guey-Horng Wang, International Conference on Manufacturing Science and Engineering . 2013

机译：Ugonin K通过在人体皮肤癌细胞中的活性氧物质/凋亡信号途径诱导细胞周期停滞和细胞凋亡
5. Cannabinol Inhibits Proliferation and Induces Cell Cycle Arrest and Apoptosis in Glioblastoma, Hepatocellular Carcinoma and Breast Cancer Cells [D] . Zhong, Nuanying. 2020

机译：大麻素抑制胶质母细胞瘤，肝细胞癌和乳腺癌细胞中的增殖和诱导细胞周期停滞和凋亡
6. Quercetin induces caspase-dependent extrinsic apoptosis through inhibition of signal transducer and activator of transcription 3 signaling in HER2-overexpressing BT-474 breast cancer cells [O] . HYE-SOOK SEO, JIN MO KU, HAN-SEOK CHOI, -1

机译：槲皮素通过抑制过表达HER2的BT-474乳腺癌细胞中的信号转导子和转录激活因子3来诱导胱天蛋白酶依赖性外源性凋亡
7. Isoobtusilactone A Induces Cell Cycle Arrest and Apoptosis through Reactive Oxygen Species/Apoptosis Signal-Regulating Kinase 1 Signaling Pathway in Human Breast Cancer Cells [O] . Po-Lin Kuo, Chung-Yi Chen, Ya-Ling Hsu 2007

机译：Isoobtusilactone A通过反应性氧物种/凋亡信号调节激酶1信号传导途径在人乳腺癌细胞中诱导细胞周期停滞和细胞凋亡

Furanodienone induces cell cycle arrest and apoptosis by suppressing EGFR/HER2 signaling in HER2-overexpressing human breast cancer cells

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