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首页> 外文期刊>Cancer Immunology, Immunotherapy >Spontaneous immune responses to sporadic tumors: tumor-promoting, tumor-protective or both?
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Spontaneous immune responses to sporadic tumors: tumor-promoting, tumor-protective or both?

机译：对散发性肿瘤的自发免疫反应：促进肿瘤，保护肿瘤或两者兼有？

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Cancer cells cannot develop into invasive cancers without interactions with cells and soluble mediators present in the tumor microenvironment. Accumulating evidence indicates that the immune system is a critical determinant of malignant outgrowth; however, the tumor-modulating effects of spontaneous immune responses towards nascent malignancies are rather paradoxical. Both cancer-protective and cancer-promoting features of the immune system have been described. This review will discuss the role of the dynamic inflammatory tumor microenvironment during cancer development and progression, and will focus on the intriguing question: “Do malignancies develop in spite of—or because of—spontaneous immune responses?” Special emphasis will be put on recent progress in our understanding of the immune system’s double-edged sword function during de novo carcinogenesis.
机译：癌细胞如果不与肿瘤微环境中存在的细胞和可溶性介体相互作用，就无法发展为浸润性癌症。越来越多的证据表明，免疫系统是恶性肿瘤生长的关键决定因素。然而，针对新生恶性肿瘤的自发免疫反应对肿瘤的调节作用是自相矛盾的。已经描述了免疫系统的保护癌症和促进癌症的特征。这篇综述将讨论动态炎症肿瘤微环境在癌症发展和进展中的作用，并将侧重于一个有趣的问题：“尽管（或由于）自发性免疫反应，恶性肿瘤仍会发展吗？”我们将特别关注我们在从头致癌过程中对免疫系统双刃剑功能的理解方面的最新进展。

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