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首页> 外文期刊>Carcinogenesis >Phase IIa chemoprevention trial of green tea polyphenols in high-risk individuals of liver cancer: modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine
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Phase IIa chemoprevention trial of green tea polyphenols in high-risk individuals of liver cancer: modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine

机译：绿茶多酚在肝癌高危人群中的IIa期化学预防试验：调节绿茶多酚和8-羟基脱氧鸟苷的尿排泄

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Modulation of urinary excretion of green tea polyphenols (GTPs) and oxidative DNA damage biomarker, 8-hydroxydeoxyguanosine (8-OHdG), were assessed in urine samples collected from a randomized, double-blinded and placebo-controlled phase IIa chemoprevention trial with GTP in 124 individuals. These individuals were sero-positive for both HBsAg and aflatoxin–albumin adducts, and took GTP capsules daily at doses of 500 mg, 1000 mg or a placebo for 3 months. Twenty-four hour urine samples were collected before the intervention and at the first and third month of the study. Urinary excretion of 8-OHdG and GTP components was measured by HPLC-CoulArray electrochemical detection. The baseline levels of 8-OHdG and GTP components among the three groups showed homogeneity (P > 0.70), and a non-significant fluctuation was observed in the placebo group over the 3 months (P > 0.30). In GTP-treated groups, epigallocatechin (EGC) and epicatechin (EC) levels displayed significant and dose-dependent increases in both the 500 mg group and 1000 mg group (P < 0.05). The 8-OHdG levels did not differ between the three groups at the 1 month collection, with medians of 1.83, 2.08 and 1.86 ng/mg-creatinine for placebo, 500 and 1000 mg group, respectively (P = 0.999). At the end of the 3 months' intervention, 8-OHdG levels decreased significantly in both GTP-treated groups, with medians of 2.02, 1.03 and 1.15 ng/mg-creatinine for placebo, 500 mg and 1000 mg group, respectively (P = 0.007). These results suggest that urinary excretions of EGC and EC can serve as practical biomarkers for green tea consumption in human populations. The results also suggest that chemoprevention with GTP is effective in diminishing oxidative DNA damage.
机译：在随机，双盲和安慰剂对照的IIa期GTP预防化学试验中收集的尿液样本中评估了绿茶多酚（GTP）和氧化性DNA损伤生物标记8-羟基脱氧鸟苷（8-OHdG）的尿排泄调节。 124个人。这些人的HBsAg和黄曲霉毒素-白蛋白加合物均呈血清阳性，并以500 mg，1000 mg或安慰剂的剂量每日服用GTP胶囊3个月。在干预之前以及研究的第一个月和第三个月，收集了二十四小时的尿液样本。通过HPLC-CoulArray电化学检测法测量了8-OHdG和GTP成分的尿排泄量。三组中的8-OHdG和GTP成分的基线水平显示出均一性（P> 0.70），并且在安慰剂组中，在3个月内观察到无显着波动（P> 0.30）。在GTP治疗组中，在500 mg组和1000 mg组中，表没食子儿茶素（EGC）和表儿茶素（EC）的水平均显示出显着且剂量依赖性的升高（P <0.05）。三组患者在1个月的采集中8-OHdG水平没有差异，安慰剂，500和1000 mg组的中位数分别为1.83、2.08和1.86 ng / mg-肌酐（P = 0.999）。在3个月的干预结束时，两个GTP治疗组的8-OHdG水平均显着下降，安慰剂，500 mg和1000 mg组的中位数分别为2.02、1.03和1.15 ng / mg肌酐（P = 0.007）。这些结果表明，EGC和EC的尿液排泄物可以作为人类食用绿茶的实用生物标志物。结果还表明，用GTP进行化学预防可有效减少DNA氧化损伤。

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