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首页> 外文期刊>Cardiovascular Toxicology >Acute Massive Pulmonary Thromboembolism Due to Acute Intoxication by Duloxetine: A Case Report
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Acute Massive Pulmonary Thromboembolism Due to Acute Intoxication by Duloxetine: A Case Report

机译：度洛西汀急性中毒引起的急性大规模肺血栓栓塞：一例报告

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Duloxetine (Cymbalta) is a potent serotonin norepinephrine reuptake inhibitor used for the management of major depression and pain associated with diabetic peripheral neuropathy. Cymbalta delayed-release capsules contain Duloxetine HCl equivalent to 20, 30, 60 mg of Duloxetine. The ingestion of high quantities of Duloxetine may have serious outcomes such as venous thrombosis, causing cardiac respiratory arrest. The Authors outline a case report of an elderly woman, suffering from depression, found dead in her apartment. The cause of death was attributed to acute massive pulmonary thromboembolism due to acute intoxication of Duloxetine bought the day before. The thesis supported by the authors and confirmed by the data from other studies is that a massive intake of Duloxetine drug increases considerably the medication’s side effects such as somnolence, dry mouth, fatigue, insomnia, dizziness, constipation, considerable increases in recumbent systolic and diastolic blood pressure, and a small decrease in heart rate.
机译：度洛西汀（Cymbalta）是一种有效的5-羟色胺去甲肾上腺素再摄取抑制剂，用于治疗与糖尿病周围神经病相关的严重抑郁和疼痛。 Cymbalta缓释胶囊含有盐酸度洛西汀，相当于20、30、60毫克度洛西汀。摄入大量度洛西汀可能会导致严重的后果，例如静脉血栓形成，从而导致心脏呼吸停止。作者概述了一例老年妇女的抑郁症病例报告，她死于她的公寓。死因归因于前一天购买的度洛西汀的急性中毒导致的急性大量肺血栓栓塞。作者支持并得到其他研究数据证实的结论是，大量摄入度洛西汀药物会大大增加药物的副作用，例如嗜睡，口干，疲劳，失眠，头昏，便秘，卧式收缩压和舒张压明显增加。血压和心率小幅下降。

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