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首页> 外文期刊>Cell Biochemistry and Biophysics >Effect of Arborvitae Seed on Cognitive Function and α7nAChR Protein Expression of Hippocampus in Model Rats with Alzheimer’s Disease
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Effect of Arborvitae Seed on Cognitive Function and α7nAChR Protein Expression of Hippocampus in Model Rats with Alzheimer’s Disease

机译：侧柏种子对阿尔茨海默病模型大鼠认知功能和海马α7nAChR蛋白表达的影响

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The aim was to investigate the effect of the arborvitae seed on cognitive function and α7-nicotinic acetylcholine receptor (α7nAChR) protein expression of the hippocampus in model rats with Alzheimer’s disease (AD). Thirty-six adult Wistar rats were randomly divided into the control, test, and drug groups. A dose of Aβ1–40 was injected into the rats’ hippocampus in the test and drug groups and the control rats were injected with the same amount of normal saline. After the model was successful, the rats in the control and test groups were gavaged with sodium carboxymethyl cellulose (500 mg/kg) and the rats in the drug group were gavaged with arborvitae seed powder (500 mg/kg) for 15 days. The Morris water maze test was used for cognitive function. The effect of arborvitae seed on α7nAChR protein immunoreactivity on the hippocampus neurons was studied by the immunohistochemistry method. Behavioral tests showed that the mean escape latencies and search time of the test group were obviously longer than the control and drug groups. The percentage of the search distance of the test group was shorter than that of the control and drug groups. The immunohistochemistry results are as follows: α7nAChR-positive cells and optical density in the hippocampus of the rats in the test group are less than that of the rats in the control and drug groups (all P < 0.01). Arborvitae seed can treat AD by increased expression of α7nAChR.
机译：目的是研究侧柏种子对阿尔茨海默病（AD）模型大鼠认知功能和海马α7-烟碱乙酰胆碱受体（α7nAChR）蛋白表达的影响。将36只成年Wistar大鼠随机分为对照组，试验组和药物组。在实验组和药物组中，给大鼠海马注射一定剂量的Aβ1–40，并给对照组注射相同量的生理盐水。模型成功后，对对照组和测试组的大鼠灌胃羧甲基纤维素钠（500 mg / kg），对药物组的大鼠灌胃侧柏种子粉（500 mg / kg），持续15天。莫里斯水迷宫测试用于认知功能。用免疫组织化学方法研究了侧柏种子对海马神经元α7nAChR蛋白免疫反应的影响。行为测试表明，测试组的平均逃避潜伏期和搜索时间明显长于对照组和药物组。试验组的搜索距离百分比短于对照组和药物组。免疫组化结果如下：试验组大鼠海马α7nAChR阳性细胞和光密度低于对照组和药物组大鼠（均P <0.01）。侧柏种子可以通过增加α7nAChR的表达来治疗AD。

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