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Defining a new vision for the retinoblastoma gene: report from the 3rd International Rb Meeting

机译：定义视网膜母细胞瘤基因的新视野：第三届国际Rb会议的报告

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The retinoblastoma tumor suppressor (Rb) pathway is mutated in most, if not all human tumors. In the G0/G1 phase, Rb and its family members p107 and p130 inhibit the E2F family of transcription factors. In response to mitogenic signals, Cyclin-dependent kinases (CDKs) phosphorylate Rb family members, which results in the disruption of complexes between Rb and E2F family members and in the transcription of genes essential for S phase progression. Beyond this role in early cell cycle decisions, Rb family members regulate DNA replication and mitosis, chromatin structure, metabolism, cellular differentiation, and cell death. While the RB pathway has been extensively studied in the past three decades, new investigations continue to provide novel insights into basic mechanisms of cancer development and, beyond cancer, help better understand fundamental cellular processes, from plants to mammals. This meeting report summarizes research presented at the recently held 3rd International Rb Meeting.
机译：视网膜母细胞瘤抑癌（Rb）途径在大多数（如果不是全部）人类肿瘤中均发生突变。在G0 / G1阶段，Rb及其家族成员p107和p130抑制E2F家族的转录因子。响应有丝分裂信号，细胞周期蛋白依赖性激酶（CDK）磷酸化Rb家族成员，这导致Rb和E2F家族成员之间的复合物被破坏，并导致S期进程必不可少的基因转录。除了在早期细胞周期决定中的作用外，Rb家族成员还调节DNA复制和有丝分裂，染色质结构，代谢，细胞分化和细胞死亡。尽管在过去的三十年中对RB途径进行了广泛的研究，但新的研究仍在继续为癌症发展的基本机制提供新颖的见解，并且除癌症以外，还有助于更好地理解从植物到哺乳动物的基本细胞过程。该会议报告总结了最近举行的第三届国际Rb会议上提出的研究。

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