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首页> 外文期刊>Cell Division >Rad53 homologue forkhead-associated kinase A (FhkA) and Ca2+-binding protein 4a (CBP4a) are nucleolar proteins that differentially redistribute during mitosis in Dictyostelium
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Rad53 homologue forkhead-associated kinase A (FhkA) and Ca2+-binding protein 4a (CBP4a) are nucleolar proteins that differentially redistribute during mitosis in Dictyostelium

机译:Rad53同源叉头相关激酶A(FhkA)和Ca2 +结合蛋白4a(CBP4a)是核仁蛋白,在网状线粒体的有丝分裂过程中差异性重新分布

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Background During mitosis most nucleolar proteins redistribute to other locales providing an opportunity to study the relationship between nucleolar protein localization and function. Dictyostelium is a model organism for the study of several fundamental biological processes and human diseases but only two nucleolar proteins have been studied during mitosis: NumA1 and Snf12. Both of them are linked to the cell cycle. To acquire a better understanding of nucleolar protein localization and dynamics in Dictyostelium we studied the nucleolar localization of two additional proteins during mitosis: Snf12-linked forkhead-associated kinase A (FhkA), which is involved in the cell cycle, and Ca2+-binding protein 4a (CBP4a), which is a binding partner of NumA1.
机译:背景技术在有丝分裂过程中,大多数核仁蛋白会重新分布到其他位置,从而提供了研究核仁蛋白定位与功能之间关系的机会。 Dictyostelium是用于研究几种基本生物学过程和人类疾病的模型生物,但在有丝分裂期间仅研究了两种核仁蛋白:NumA1和Snf12。它们都与细胞周期有关。为了更好地了解梭菌中核仁蛋白的定位和动力学,我们研究了有丝分裂期间另外两种蛋白的核仁定位:Snf12连锁的叉头相关激酶A(FhkA)(参与细胞周期)和Ca2 +结合蛋白4a(CBP4a),它是NumA1的结合伴侣。

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