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首页> 外文期刊>Cell Research >Antibody gene therapy: an attractive approach for the treatment of cancers and other chronic diseases
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Antibody gene therapy: an attractive approach for the treatment of cancers and other chronic diseases

机译：抗体基因疗法：治疗癌症和其他慢性疾病的一种有吸引力的方法

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摘要

Monoclonal antibodies (mAb) have been successfully applied to the treatment of chronic diseases, such as cancer, inflammation and immune diseases. With the technical advances in antibody engineering, development of small recombinant antibody fragments as high affinity therapeutics with reduced immunogenicity has become under the spotlight. A popular format of the engineered recombinant antibody fragments is the single-chain fixed-variable (scFv) molecules, in which the VH and VL regions of the parental antibody are jointed together by a polypeptide linker. The scFv fragment retains the target specificity and antigen-binding affinity of the intact antibody, and can be genetically designed and produced in large quantity by ectopically expressing both VH and VL regions from a single cDNA in cells. Due to its smaller size, the scFv molecule shows improved pharmacokinetics in tumor penetration and is better tolerated by the host immune system.
机译：单克隆抗体（mAb）已成功应用于慢性疾病的治疗，例如癌症，炎症和免疫性疾病。随着抗体工程技术的进步，人们越来越关注小重组抗体片段作为具有降低的免疫原性的高亲和力治疗剂的开发。工程重组抗体片段的一种流行形式是单链固定变量（scFv）分子，其中亲本抗体的VH和VL区通过多肽接头连接在一起。 scFv片段保留了完整抗体的靶标特异性和抗原结合亲和力，并且可以通过在细胞中异位表达单个cDNA中的VH和VL区来进行遗传设计和大量生产。由于其较小的尺寸，scFv分子在肿瘤渗透中显示出改善的药代动力学，并且被宿主免疫系统更好地耐受。

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  • 来源
    《Cell Research》 |2007年第4期|p.303-306|共4页
  • 作者

    Dexian Zheng;

  • 作者单位

    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese A cademy of Medical Sciences and Peking Union Medical College, Beijing 100005, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

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