The identification of a new actin-binding region in p57.

Liu CZ; Chen Y; Sui SF

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The identification of a new actin-binding region in p57.

机译：p57中新的肌动蛋白结合区的鉴定。

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The actin-binding protein p57 is a member of mammalian coronin-like proteins. The roles of this protein in phagocytic processes conceivably depend on its interactions with F-actin. Two regions, p57(1-34) and p57(111-204), were previously reported to be actin-binding sites. In this study, we found that the C-terminal region of p57, p57(297-461), also possessed F-actin binding activity. Furthermore, the leucine zipper domain at the C-terminus of p57(297-461) was essential for this actin-binding activity. The F-actin cross-linking assay revealed that the region contained in p57(297-461) was sufficient to cross-link actin filaments. Our results strongly suggested that there was a new actin-binding region at the C-terminus of p57.Cell Research (2006) 16: 106-112. doi:10.1038/sj.cr.7310014; published online 16 January 2006.

机译：肌动蛋白结合蛋白p57是哺乳动物冠状蛋白样蛋白的成员。该蛋白在吞噬过程中的作用可想而知取决于它与F-肌动蛋白的相互作用。先前报道p57（1-34）和p57（111-204）这两个区域是肌动蛋白结合位点。在这项研究中，我们发现p57的C末端区域p57（297-461）也具有F-肌动蛋白结合活性。此外，p57（297-461）C端的亮氨酸拉链结构域对于这种肌动蛋白结合活性至关重要。 F-肌动蛋白交联测定表明，p57（297-461）中包含的区域足以交联肌动蛋白丝。我们的结果强烈表明在p57的C末端有一个新的肌动蛋白结合区.Cell Research（2006）16：106-112。 doi：10.1038 / sj.cr.7310014;在线发布于2006年1月16日。

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《Cell Research》 |2006年第1期|P.106-112|共7页
作者
Liu CZ; Chen Y; Sui SF;
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作者单位

1Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembranes, Tsinghua University, Beijing 100084, China.;

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收录信息美国《科学引文索引》(SCI);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
Actins; binding; Carbon ion; 肌动蛋白类;

机译：Actins;binding;Carbon ion;肌动蛋白类;

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1. The identification of a new actin-binding region in p57. [J] . Liu CZ, Chen Y, Sui SF Cell research. . 2006,第1期

机译：p57中新的肌动蛋白结合区的鉴定。
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机译：人红细胞血影蛋白肌动蛋白结合域的鉴定和部分纯化。
6. Switch II Mutants Reveal Coupling between the Nucleotide- and Actin-Binding Regions in Myosin V [O] . Darshan V. Trivedi, Charles David, Donald J. Jacobs, 2012

机译：开关II突变体揭示肌球蛋白V中的核苷酸和肌动蛋白结合区域之间的耦合。
7. The identification of a new actin-binding region in p57 [O] . Chang Zhen Liu, Yong Chen, Sen Fang Sui 2006

机译：在p57中鉴定新的肌动蛋白结合区

The identification of a new actin-binding region in p57.

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