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Transforming growth factor-β signaling in tumor initiation, progression and therapy in breast cancer: an update

机译:转化生长因子-β信号转导在乳腺癌的肿瘤发生,发展和治疗中的最新进展

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摘要

Transforming growth factor-β (TGF-β) is a ubiquitous cytokine playing an essential role in cell proliferation, differentiation, apoptosis, adhesion and invasion, as well as in cellular microenvironment. In malignant diseases, TGF-β signaling features a growth inhibitory effect at an early stage but aggressive oncogenic activity at the advanced malignant state. Here, we update the current understanding of TGF-β signaling in cancer development and progression with a focus on breast cancer. We also review the current approaches of TGF-β signaling-targeted therapeutics for human malignancies.
机译:转化生长因子-β(TGF-β)是一种普遍存在的细胞因子,在细胞增殖,分化,凋亡,粘附和侵袭以及细胞微环境中起着至关重要的作用。在恶性疾病中,TGF-β信号传导在早期具有生长抑制作用,但在晚期恶性状态具有侵袭性的致癌活性。在这里,我们更新了对TGF-β信号在癌症发展和进展中的当前了解,重点是乳腺癌。我们还回顾了针对人类恶性肿瘤的TGF-β信号传导靶向疗法的当前方法。

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