...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell and Tissue Research >Inflammatory phase of bone healing initiates the regenerative healing cascade
【24h】

Inflammatory phase of bone healing initiates the regenerative healing cascade

机译：骨愈合的炎症阶段启动了再生愈合的级联

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Bone healing commences with an inflammatory reaction which initiates the regenerative healing process leading in the end to reconstitution of bone. An unbalanced immune reaction during this early bone healing phase is hypothesized to disturb the healing cascade in a way that delays bone healing and jeopardizes the successful healing outcome. The immune cell composition and expression pattern of angiogenic factors were investigated in a sheep bone osteotomy model and compared to a mechanically-induced impaired/delayed bone healing group. In the impaired/delayed healing group, significantly higher T cell percentages were present in the bone hematoma and the bone marrow adjacent to the osteotomy gap when compared to the normal healing group. This was mirrored in the higher cytotoxic T cell percentage detected under delayed bone healing conditions indicating longer pro-inflammatory processes. The highly activated periosteum adjourning the osteotomy gap showed lower expression of hematopoietic stem cell markers and angiogenic factors such as heme oxygenase and vascular endothelial growth factor. This indicates a deferred revascularization of the injured area due to ongoing pro-inflammatory processes in the delayed healing group. Results from this study suggest that there are unfavorable immune cells and factors participating in the initial healing phase. In conclusion, identifying beneficial aspects may lead to promising therapeutical approaches that might benefit further by eliminating the unfavorable factors.
机译：骨骼愈合始于炎症反应，炎症反应引发再生愈合过程，最终导致骨骼重建。据推测，在此早期骨愈合阶段中不平衡的免疫反应会以延迟骨愈合并危及成功的愈合结果的方式干扰愈合级联。在绵羊骨截骨模型中研究了免疫细胞组成和血管生成因子的表达模式，并将其与机械诱导的受损/延迟骨愈合组进行了比较。与正常愈合组相比，在受损/延迟愈合组中，在血肿和与切骨术间隙相邻的骨髓中存在显着更高的T细胞百分比。这反映在延迟的骨愈合条件下检测到的更高的细胞毒性T细胞百分比，表明更长的促炎过程。高度活跃的骨膜间隙切开术显示造血干细胞标志物和血管生成因子（如血红素加氧酶和血管内皮生长因子）的表达较低。这表明由于延迟愈合组中正在进行的促炎过程，导致受损区域的血运重建推迟。这项研究的结果表明，有不利的免疫细胞和参与初始愈合阶段的因素。总之，确定有益方面可能会导致有希望的治疗方法，这些方法可能会通过消除不利因素而进一步受益。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号