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首页> 外文期刊>Cell and Tissue Research >Biodegradable biomatrices and bridging the injured spinal cord: the corticospinal tract as a proof of principle
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Biodegradable biomatrices and bridging the injured spinal cord: the corticospinal tract as a proof of principle

机译：可生物降解的生物基质和桥接受伤的脊髓：皮质脊髓束作为原理的证明

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摘要

Important advances in the development of smart biodegradable implants for axonal regeneration after spinal cord injury have recently been reported. These advances are evaluated in this review with special emphasis on the regeneration of the corticospinal tract. The corticospinal tract is often considered the ultimate challenge in demonstrating whether a repair strategy has been successful in the regeneration of the injured mammalian spinal cord. The extensive know-how of factors and cells involved in the development of the corticospinal tract, and the advances made in material science and tissue engineering technology, have provided the foundations for the optimization of the biomatrices needed for repair. Based on the findings summarized in this review, the future development of smart biodegradable bridges for CST regrowth and regeneration in the injured spinal cord is discussed.
机译：最近已经报道了开发用于脊髓损伤后轴突再生的智能生物可降解植入物的重要进展。本文对这些进展进行了评估，并特别着重于皮质脊髓束的再生。皮质脊髓束通常被认为是证明修复策略在受伤的哺乳动物脊髓再生中是否成功的最终挑战。皮质脊髓束发育涉及的因素和细胞的广泛专业知识，以及材料科学和组织工程技术的进步，为优化修复所需的生物基质提供了基础。基于本综述中总结的发现，讨论了用于受伤的脊髓中CST再生和再生的智能生物可降解桥的未来发展。

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