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首页> 外文期刊>Cell and Tissue Research >Are TRP channels involved in sperm development and function?
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Are TRP channels involved in sperm development and function?

机译：TRP通道参与精子的发育和功能吗？

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摘要

Spermatozoa must translate information from their environment and the egg to achieve fertilization in sexually reproducing animals. These tasks require decoding a variety of signals in the form of intracellular Ca2+ changes. As TRP channels constitute a large family of versatile multi-signal transducers, they are interesting subjects in which to explore their possible participation in sperm function. Here, we review the evidence for their presence and involvement in sperm motility, maturation, and the acrosome reaction, an exocytotic process required for sperm–egg fusion. Since store-operated Ca2+ entry (SOCE) has been proposed to play an important role in these three functions, the main proteins responsible for this transport (STIM and ORAI) and their interaction with TRPs are also discussed. Improving our tools to solve infertility, improve animal breeding, and preserve biodiversity requires a better understanding of how Ca2+ is regulated in spermatozoa.
机译：精子必须从其环境和卵子中获取信息，以使有性繁殖的动物受精。这些任务需要解码细胞内Ca 2 + 变化形式的多种信号。由于TRP通道构成了一个广泛的多功能多信号换能器家族，因此它们是有趣的主题，在其中探讨了它们可能参与的精子功能。在这里，我们回顾了它们存在并参与精子运动，成熟和顶体反应（精子与卵子融合所需的胞吐过程）的证据。由于已经提出了存储操纵的Ca 2 + 条目（SOCE）在这三个功能中起重要作用，因此负责该转运的主要蛋白质（STIM和ORAI）以及它们与TRP的相互作用也是讨论过。改善我们的工具以解决不育症，改善动物育种和保护生物多样性需要更好地了解精子中Ca 2 + 的调控方式。

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