...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell and Tissue Research >Persistent activation of omentum influences the pattern of muscular lesion in the mdx diaphragm
【24h】

Persistent activation of omentum influences the pattern of muscular lesion in the mdx diaphragm

机译：大网膜的持续激活会影响mdx隔膜中肌肉病变的模式

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The mdx (X chromosome-linked muscular dystrophy) mouse develops a multi-staged disorder characterized by muscle degeneration and reactive fibrosis. Skeletal muscles of mdx mice are not equally susceptible to degeneration. The aim of this study was to verify whether the intense remodeling of the mdx diaphragm could be attributed to influences from the peritoneal microenvironment and omentum, a lymphohematopoietic tissue rich in progenitor cells and trophic factors. At ages corresponding to increased muscular regeneration (12 weeks) and activation of fibrosis (24 weeks), the mdx omentum exhibited (1) morphological and functional characteristics of activation with enlarged milk-spots, an accumulation of CD4+, CD8+ and CD19+B220+ B lymphocytes; (2) the formation of clusters positive for proliferating cell nuclear antigen, mainly in B220+-rich areas organized in a follicular structure with a germinative center without any challenge by external antigen inducers; (3) clusters with cells positive for fibroblast growth factor-2, numerous Sca-1+CD3-CD19-Mac-1- progenitor cells and increased CD4+, CD8+ and CD3+NK1.1+ cells in the peritoneal cavity. Omentectomy reduced areas with F4/80+ inflammatory infiltrate the activity of matrix metalloproteases 9 and 2, collagen deposition and areas with regenerating myofibers in the diaphragm. Thus, persistent activation of the omentum influences the pattern of inflammation and regeneration of the mdx diaphragm partly via the activation of progenitor cells and the production of growth factors that influence the physiopathology of the muscular tissue remodeling.
机译：mdx（X染色体连锁的肌肉营养不良）小鼠发展为多阶段性疾病，其特征是肌肉变性和反应性纤维化。 mdx小鼠的骨骼肌同样不容易变性。这项研究的目的是验证mdx隔膜的强烈重塑是否可以归因于腹膜微环境和网膜（富含祖细胞和营养因子的淋巴造血组织）的影响。在相应于肌肉再生增强（12周）和纤维化激活（24周）的年龄，mdx大网膜表现出（1）乳腺斑点激活的形态学和功能特征，CD4 + ，CD8 + 和CD19 + B220 + B淋巴细胞； （2）对细胞核抗原增殖呈阳性的簇的形成，主要在富集B220 + 的区域中，以卵泡结构组织，具有发芽中心，不受外部抗原诱导剂的攻击； （3）具有成纤维细胞生长因子2阳性细胞的簇，大量Sca-1 + CD3 - CD19 - Mac-1 -祖细胞和增加的CD4 + ，CD8 + 和CD3 + NK1.1 + 细胞在腹腔。大网膜切除术减少了F4 / 80 + 炎症区域，浸润了基质金属蛋白酶9和2的活性，胶原沉积以及the肌中再生纤维的区域。因此，网膜的持续活化部分地通过祖细胞的活化和影响肌肉组织重塑的生理病理的生长因子的产生来影响mdx隔膜的炎症和再生模式。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号