Innate immunity of the liver microcirculation

Paulina M. Kowalewska; Amanda L. Patrick; Alison E. Fox-Robichaud

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Innate immunity of the liver microcirculation

机译：肝脏微循环的先天免疫

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The liver is a complex organ with a unique microcirculation and both synthetic and immune functions. Innate immune responses have been studied in response to single inflammatory mediators and several clinically relevant models of infection and injury. While standard histological techniques have been used in many models, the liver microcirculation is also amenable to in vivo examination using epifluorescent, confocal and transillumination intravital microscopy. These techniques have begun to clarify not only the molecular mechanisms but also the specific cell populations involved in the liver inflammation. In this review, we discuss the cells and mediators involved in hepatic innate immunity in simple and complex models of injury and infection, and present the view that the liver microcirculation utilizes non-classical pathways for leukocyte recruitment.

机译：肝脏是一个复杂的器官，具有独特的微循环以及合成和免疫功能。已经对先天免疫应答对单个炎性介质和几种感染和损伤的临床相关模型的应答进行了研究。尽管在许多模型中已经使用了标准的组织学技术，但肝脏的微循环也适合使用落射荧光，共聚焦和透射照明的活体内显微镜进行体内检查。这些技术不仅已开始阐明与肝脏炎症有关的分子机制，而且已阐明了特定的细胞群。在这篇综述中，我们讨论了在损伤和感染的简单和复杂模型中涉及肝先天免疫的细胞和介质，并提出了肝脏微循环利用非经典途径招募白细胞的观点。

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《Cell and Tissue Research》 |2011年第1期|p.85-96|共12页
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Paulina M. Kowalewska; Amanda L. Patrick; Alison E. Fox-Robichaud;
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1. Innate immunity of the liver microcirculation. [J] . Kowalewska PM, Patrick AL, Fox Robichaud AE Cell and Tissue Research . 2011,第1期

机译：肝脏微循环的先天免疫力。
2. Drosophila Pkaap regulates Rab4/Rab11-dependent traffic and Rab11 exocytosis of innate immune cargo Drosophila Pkaap regulates Rab4/Rab11-dependent traffic and Rab11 exocytosis of innate immune cargo Drosophila Pkaap regulates Rab4/Rab11-dependent traffic and Rab11 exocytosis of innate immune cargo [J] . Douglas A. Brooks, Alexandra Sorvina, Tetyana Shandala Biology Open . 2016,第6期

机译：果蝇Pkaap调节天然免疫货物的Rab4 / Rab11依赖性运输和Rab11胞吐作用果蝇Pkaap调节天然免疫货物的Rab4 / Rab11依赖性运输和Rab11胞吐作用果蝇Pkaap调节天然免疫货物的Rab4 / Rab11依赖性运输和Rab11胞吐作用
3. Drosophila Pkaap regulates Rab4/Rab11-dependent traffic and Rab11 exocytosis of innate immune cargo Drosophila Pkaap regulates Rab4/Rab11-dependent traffic and Rab11 exocytosis of innate immune cargo Drosophila Pkaap regulates Rab4/Rab11-dependent traffic and Rab11 exocytosis of innate immune cargo [J] . Douglas A. Brooks, Alexandra Sorvina, Tetyana Shandala Biology Open . 2016,第6期

机译：果蝇Pkaap调节天然免疫货物的Rab4 / Rab11依赖性运输和Rab11胞吐作用果蝇Pkaap调节天然免疫货物的Rab4 / Rab11依赖性运输和Rab11胞吐作用果蝇Pkaap调节天然免疫货物的Rab4 / Rab11依赖性运输和Rab11胞吐作用
4. A Temporal Analysis of the Bovine Innate Immune ResponseA Temporal Analysis of the Bovine Innate Immune Response: The Identification and Characterization of Host Defense Peptides by Mass Spectrometry [C] . Jeffrey A. DeGrasse, Jamie L. Boehmer, Kevin J. Shefcheck, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：牛先天免疫应答牛先天性免疫应答的时间分析：质谱法鉴定和表征宿主防毒肽
5. INJURY AND RESPONSE INDUCED BY IMMUNE COMPLEXES IN THE MICROCIRCULATION OF THE RABBIT: A QUALITATIVE AND QUANTITATIVE EXAMINATION OF THE ARTHUS PHENOMENON [D] . CRAWFORD, JOHN PATRICK MICHAEL. 1983

机译：兔微循环中免疫复合物引起的伤害和反应：对关节痛现象的定性和定量检验
6. Innate Immune Reconstitution in Humanized Bone Marrow-Liver-Thymus (HuBLT) Mice Governs Adaptive Cellular Immune Function and Responses to HIV-1 Infection [O] . Wilfredo F. Garcia-Beltran, Daniel T. Claiborne, Colby R. Maldini, 2021

机译：人类骨髓骨髓 - 肝胸腺（Hublt）小鼠的先天免疫重建治理适应性细胞免疫功能和对HIV-1感染的反应
7. Six practical diets were formulated to contain 2.6 (the basal diet), 48.9, 95.5, 189.83, 382.4, 779.53 mg/kg vitamin C diet. After 8 weeks of feeding, growth performance, antioxidant status, and innate immunity of juvenile pufferfish were analyzed. Results showed that specific growth rate and protein efficiency ratio in fish fed diets supplemented with vitamin C were significantly higher than in fish fed the control diet. Dietary vitamin C significantly up-regulated the expression levels of growth hormone receptors and Insulin-like growth factor. Blood cell numbers and respiratory burst activity were enhanced in fish fed vitamin C diet. Serum alkaline phosphatase, glutamic-pyruvic transaminase, and glutamic-oxaloacetic transaminase activity were significantly influenced by the dietary vitamin C levels. Fish fed diets supplemented with vitamin C showed increased hepatic superoxide dismutase, glutathione peroxidase, and catalase activity, but decreased malondialdehyde activity. In addition, we found that dietary vitamin C can significantly up-regulate the expression levels of immune-related genes (HSP70, HSP90, BAFF, TNF-α and IL-6) in liver. These results indicate that dietary vitamin C can significantly influence growth performance, antioxidant status, and innate immunity of pufferfish. [O] . Cheng C-H, Liang H-Y., Guo Z-X., 2017

机译：配制了六种实用饮食，分别含有2.6（基础饮食），48.9、95.5、189.83、382.4、779.53 mg / kg维生素C饮食。喂食8周后，分析了幼崽河豚的生长性能，抗氧化剂状态和先天免疫力。结果表明，补充维生素C的鱼饲料的比生长速率和蛋白质效率比显着高于对照组的鱼。饮食中的维生素C显着上调了生长激素受体和胰岛素样生长因子的表达水平。喂鱼的维生素C饮食可提高血细胞数量和呼吸爆发活性。饮食中的维生素C水平显着影响血清碱性磷酸酶，谷氨酸-丙酮酸转氨酶和谷氨酸-草酰乙酸转氨酶的活性。补充维生素C的鱼饲料日粮中肝超氧化物歧化酶，谷胱甘肽过氧化物酶和过氧化氢酶活性增加，但丙二醛活性降低。此外，我们发现饮食中的维生素C可以显着上调肝脏中免疫相关基因（HSP70，HSP90，BAFF，TNF-α和IL-6）的表达水平。这些结果表明，饮食中的维生素C可以显着影响河豚的生长性能，抗氧化状态和先天免疫力。

Innate immunity of the liver microcirculation

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