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首页> 外文期刊>Cell and Tissue Research >Relationship between interstitial cells of Cajal, fibroblast-like cells and inhibitory motor nerves in the internal anal sphincter
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Relationship between interstitial cells of Cajal, fibroblast-like cells and inhibitory motor nerves in the internal anal sphincter

机译：肛门内括约肌的Cajal间质细胞，成纤维样细胞与抑制性运动神经之间的关系

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摘要

Interstitial cells of Cajal (ICC) have been shown to participate in nitrergic neurotransmission in various regions of the gastrointestinal (GI) tract. Recently, fibroblast-like cells, which are positive for platelet-derived growth factor receptor α (PDGFRα+), have been suggested to participate additionally in inhibitory neurotransmission in the GI tract. The distribution of ICC and PDGFRα+ cell populations and their relationship to inhibitory nerves within the mouse internal anal sphincter (IAS) are unknown. Immunohistochemical techniques and confocal microscopy were therefore used to examine the density and arrangement of ICC, PDGFRα+ cells and neuronal nitric-oxide-synthase-positive (nNOS+) nerve fibers in the IAS of wild-type (WT) and W/W v mice. Of the total tissue volume within the IAS circular muscle layer, 18% consisted in highly branched PDGFRα+ cells (PDGFRα+-IM). Other populations of PDGFRα+ cells were observed within the submucosa and along the serosal and myenteric surfaces. Spindle-shaped intramuscular ICC (ICC-IM) were present in the WT mouse IAS but were largely absent from the W/W v IAS. The ICC-IM volume (5% of tissue volume) in the WT mouse IAS was significantly smaller than that of PDGFRα+-IM. Stellate-shaped submucosal ICC (ICC-SM) were observed in the WT and W/W v IAS. Minimum surface distance analysis revealed that nNOS+ nerve fibers were closely aligned with both ICC-IM and PDGFRα+-IM. An even closer association was seen between ICC-IM and PDGFRα+-IM. Thus, a close morphological arrangement exists between inhibitory motor neurons, ICC-IM and PDGFRα+-IM suggesting that some functional interaction occurs between them contributing to inhibitory neurotransmission in the IAS.
机译：已经显示，Cajal间质细胞（ICC）参与胃肠道（GI）区域的硝化神经传递。最近，有人提出对血小板衍生的生长因子受体α（PDGFRα + ）呈阳性的成纤维细胞样细胞还参与了胃肠道的抑制性神经传递。小鼠内肛门括约肌（IAS）中ICC和PDGFRα + 细胞群的分布及其与抑制神经的关系尚不清楚。因此，采用免疫组织化学技术和共聚焦显微镜检查ICC，PDGFRα + 细胞和神经元一氧化氮合酶阳性（nNOS + ）神经纤维的密度和排列。野生型（WT）和W / W v 小鼠的IAS。在IAS环形肌层内的总组织体积中，有18％由高度分支的PDGFRα + 细胞（PDGFRα + -IM）组成。在粘膜下层以及沿浆膜和肠系膜表面观察到其他PDGFRα + 细胞群体。 WT小鼠IAS中存在纺锤形的肌内ICC（ICC-IM），但W / W v IAS中基本上没有。 WT小鼠IAS中的ICC-IM体积（占组织体积的5％）显着小于PDGFRα + -IM。在WT和W / W v IAS中观察到星状粘膜下ICC（ICC-SM）。最小表面距离分析表明，nNOS + 神经纤维与ICC-IM和PDGFRα + -IM紧密排列。 ICC-IM与PDGFRα + -IM之间存在更紧密的联系。因此，抑制性运动神经元ICC-IM和PDGFRα + -IM之间存在紧密的形态排列，表明它们之间发生了某些功能性相互作用，从而导致了IAS中抑制性神经传递。

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