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Syndecans as receptors and organizers of the extracellular matrix

机译：Syndecans作为细胞外基质的受体和组织者

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摘要

Syndecans are type I transmembrane proteins having a core protein modified with glycosaminoglycan chains, most commonly heparan sulphate. They are an ancient group of molecules, present in invertebrates and vertebrates. Among the plethora of molecules that can interact with heparan sulphate, the collagens and glycoproteins of the extracellular matrix are prominent. Frequently, they do so in conjunction with other receptors, most notably the integrins. For this reason, they are often referred to as “co-receptors”. However, just as with integrins, syndecans can interact with actin-associated proteins and signalling molecules, such as protein kinases. Some aspects of syndecan signalling are understood but much remains to be learned. The functions of syndecans in regulating cell adhesion and extracellular matrix assembly are described here. Evidence from null mice suggests that syndecans have roles in postnatal tissue repair, inflammation and tumour progression. Developmental deficits in lower vertebrates in which syndecans are eliminated are also informative and suggest that, in mammals, redundancy is a key issue. Keywords Proteoglycan - Heparan sulphate - Signalling - Extracellular matrix assembly Xiaojie Xian and Sandeep Gopal contributed equally to this work.
机译：合成癸烷是I型跨膜蛋白，其核心蛋白被糖胺聚糖链（最常见的是硫酸乙酰肝素）修饰。它们是一群古老的分子，存在于无脊椎动物和脊椎动物中。在可以与硫酸乙酰肝素相互作用的众多分子中，细胞外基质的胶原蛋白和糖蛋白非常突出。通常，它们与其他受体，尤其是整联蛋白一起进行。因此，它们通常被称为“共同受体”。但是，就像整合素一样，Syndecans可以与肌动蛋白相关的蛋白质和信号分子（例如蛋白激酶）相互作用。 Syndecan信号传导的某些方面已被理解，但仍有许多要学习。 Syndecans在调节细胞黏附和细胞外基质组装中的功能在此进行了描述。空小鼠的证据表明，聚癸内酯在产后组织修复，炎症和肿瘤进展中起作用。消除了十二指肠的低等脊椎动物的发育缺陷也提供了信息，表明在哺乳动物中冗余是一个关键问题。关键词蛋白聚糖-硫酸乙酰肝素-信号传导-细胞外基质装配肖小贤和桑迪普·戈帕尔为这项工作做出了同样的贡献。

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