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首页> 外文期刊>Cell and Tissue Research >Multipotent neuroblasts generate a biochemical neuroarchitecture in the central complex of the grasshopper Schistocerca gregaria
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Multipotent neuroblasts generate a biochemical neuroarchitecture in the central complex of the grasshopper Schistocerca gregaria

机译：多能神经母细胞在蝗虫血吸虫中央复合体中产生生化神经结构

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摘要

We have examined the developmental expression of the neuromodulators locustatachykinin, leucokinin-1, allatostatin and serotonin in a subset of lineages (Y, Z) of the central complex in the brain of the grasshopper Schistocerca gregaria. First, we show that all these neuromodulators are expressed in the same lineages during embryogenesis. The neuroblasts generating these lineages are therefore biochemically multipotent. Second, the neurons expressing the different neuromodulators are found clustered at stereotypic locations in their respective lineages. Locustatachykinin and leucokinin-1 map to the apical region of the lineage, allatostatin medially and serotonin to the base of the lineage. Since the location in these lineages translates into their birth order, we have been able ontogenetically to analyse their biochemical expression patterns. The age-profile within a lineage reveals that locustatachykinin- and leucokinin-1-expressing neurons are born first, then allatostatin neurons and finally serotoninergic neurons. Co-expression has been tested for serotonin with locustatachykin, leucokinin-1 or allatostatin and is negative but is positive for locustatachykinin and leucokinin-1, consistent with the stereotypic location of cells in the lineages. The delay between the birth of a neuron and the expression of its neuromodulator is stereotypic for each substance. Combined with a known birth date, this delay translates into a developmental expression pattern for the central complex itself.
机译：我们已经检查了蝗虫Schistocerca gregaria大脑中枢复合物的一部分谱系（Y，Z）中神经调节剂locustatachykinin，leucokinin-1，alatostatin和5-羟色胺的发育表达。首先，我们表明所有这些神经调节剂在胚胎发生过程中都在相同的谱系中表达。因此，产生这些谱系的成神经细胞是生化多能的。其次，发现表达不同神经调节剂的神经元聚集在它们各自谱系的定型位置上。 Locustatachykinin和leucokinin-1定位到谱系的顶端区域，阿托伐他汀位于内侧，而血清素则定位于谱系的基础。由于这些谱系中的位置转化为它们的出生顺序，因此我们已经能够从本体论上分析它们的生化表达模式。谱系中的年龄分布表明，先表达locustatachykinin和leucokinin-1的神经元先出生，然后是阿托伐他汀神经元，最后是5-羟色胺能神经元。已针对血清表达与locustatachykin，leucokinin-1或allatostatin的共表达进行了测试，并且共表达locustatachykinin和leucokinin-1为阴性，但与谱系中细胞的定型位置一致。对于每种物质，神经元的诞生与其神经调节剂的表达之间的延迟是刻板的。结合已知的出生日期，这种延迟转化为中央复合体本身的发育表达模式。

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